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首页- 产品 - Metabolic Enzyme/Protease - PAI-1

PAI-1

PAI-1, encoded by SERPINE1, is a primary member of the serpin super-family and functions as an essential inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen PAI-1 is up-regulated in various pathological states such as vascular diseases, obesity, metabolic syndrome and particularly various types of cancer. PAI-1 expression is quite different in diverse cancer cell lines. PAI-1 is also correlated with poor outcome in several other cancer subtypes, particularly in node-negative breast cancer, ovarian serous carcinoma. As an important regulator of the fibrinolytic system, PAI-1 plays a pivotal role in acute thrombotic events. PAI-1 facilitated invasion and lung metastasis via promoting MMP-13 expression and secretion in osteosarcoma cells, and PAI-1 as well as MMP-13 concomitant expression was significantly associated with lung metastasis of osteosarcoma through clinical samples analysis. 
High PAI-1 expression might increase the risk of head and neck carcinoma metastasis via immunohistochemical analysis and further overexpression of PAI-1 accelerated head and neck cancer cell migration mediated by the activation of PI3K/AKT pathway.  PAI-1 has also been found to promote cell proliferation in fibromatosis and pheochromocytoma. The roles of PAI-1 in cancer might vary with each experimental condition, especially the cancer type. Moreover, PAI-1 may also be involved in immunosuppression, a key condition for rapid tumor progression. Recently, it was reported that TGF-β could enhance PAI-1 secretion in NSCLC dependent on Smad3 phosphorylation, and PAI-1 in return could strengthen TGF-β signaling in tumor associated macrophages via the activation of NF-κB/IL-6/STAT3 pathway, forming an immunosuppressive feed-forward loop.

References

1.Li S,et al. Biomed Pharmacother. 2018;105:83–94.

Metabolic Enzyme/Protease

11β-HSD(15) 15-PGDH(1) ACC(10) ACE(15) AChE(47) Adenylate Cyclase(12) ALDH(14) Aldose Reductase(5) Aminopeptidase(19) BACE(19) Casein Kinase(51) CAT(5) Cathepsin(9) CETP(13) COMT(2) CPG2(1) CYPs(6) Decarboxylase(3) Dehydrogenase(131) DGAT(4) Dopamine beta-hydroxylase(2) DPP(32) Elastase(6) FAAH(28) Factor Xa(31) Fatty Acid Synthase(17) Ftase(2) FXR(26) Glucokinase(1) GSNOR(2) Guanylate Cyclase(13) HMGCR(17) IDH(7) IDO(20) IMPDH(2) LDH(2) LDL(8) Lipase(17) Lipid(12) MAGL(6) MAO(72) MMP(78) NAMPT(12) Neprilysin(7) Other Targets(10) P450(112) PAI-1(9) Phosphatase(95) Phospholipase(65) PPAR(115) Protein Phosphatase/PTP(6) Renin(8) Retinoid Receptor(37) SCD(6) Steroid Sulfatase (STS)(2) Thioredoxin(1) TPH(5) Transferase(37) Vitamin(44) Xanthine Oxidase (XAO)(11)

PAI-1

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