Angstrom6

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Angstrom6 (A6 Peptide) 是一种来源于单链尿激酶纤溶酶原激活剂 (scuPA) 的8个氨基酸的肽，可干扰 uPA/uPAR 级联反应并消除下游效应。Angstrom6 与 CD44 结合，抑制肿瘤细胞的迁移、侵袭和转移，调节 CD44 介导的细胞信号。

Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling.

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Animal Model:C57Bl/6 mice (bearing B16-F10 cells)Dosage:100 mg/kg Administration:S.c.; twice a day for 11 days Result:Reduced the number of lung nodules and reduced the number of lung metastases to 50% of control.

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Metabolic Enzyme/Protease

PAI-1

PAI-1

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220334-14-5

910.97

C39H62N10O15

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (109.77 mM; 超声助溶 ) H2O 中的溶解度 : ≥ 100 mg/mL (109.77 mM)

CC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(N)=O

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(-20℃)

With Ice Pack

≥ 2 years