Lipid
Lipids have critical roles in nervous system structure and function. They contribute to the unique composition of synaptic complexes and myelin, and participate in multiple signaling pathways involving lipid intermediates. Lipid modification of proteins is a key mechanism for modulating the activity of trophic factors and receptors.
Metabolic Enzyme/Protease
11β-HSD(15)
15-PGDH(1)
ACC(10)
ACE(15)
AChE(47)
Adenylate Cyclase(12)
ALDH(14)
Aldose Reductase(5)
Aminopeptidase(19)
BACE(19)
Casein Kinase(51)
CAT(5)
Cathepsin(9)
CETP(13)
COMT(2)
CPG2(1)
CYPs(6)
Decarboxylase(3)
Dehydrogenase(131)
DGAT(4)
Dopamine beta-hydroxylase(2)
DPP(32)
Elastase(6)
FAAH(28)
Factor Xa(31)
Fatty Acid Synthase(17)
Ftase(2)
FXR(26)
Glucokinase(1)
GSNOR(2)
Guanylate Cyclase(13)
HMGCR(17)
IDH(7)
IDO(20)
IMPDH(2)
LDH(2)
LDL(8)
Lipase(17)
Lipid(12)
MAGL(6)
MAO(72)
MMP(78)
NAMPT(12)
Neprilysin(7)
Other Targets(10)
P450(112)
PAI-1(9)
Phosphatase(95)
Phospholipase(65)
PPAR(115)
Protein Phosphatase/PTP(6)
Renin(8)
Retinoid Receptor(37)
SCD(6)
Steroid Sulfatase (STS)(2)
Thioredoxin(1)
TPH(5)
Transferase(37)
Vitamin(44)
Xanthine Oxidase (XAO)(11)
Lipid
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Carboxylesterase-IN-3
产品货号 : M35472
cas no: 2764748-92-5
Carboxylesterase-IN-3 (compound 4y) 是一种有效的 Carboxylesterase Notum 抑制剂,IC50 小于或等于 10 nM。Notum 是 Wnt 信号传导的负调节剂,通过棕榈油酸酯的水解作用,这是 Wnt 活性所必需的。Carboxylesterase-IN-3 具有研究癌症疾病的潜力。 -
Lifibrol
产品货号 : M34316
cas no: 96609-16-4
Lifibrol (U-83860) is an inhibitor of cholesterol synthesis.Lifibrol has anticholesterol and hypolipidemic properties and promotes the conversion of LDL Apo B-100 in patients with hypercholesterolemia and mixed hyperlipidemia. -
HSL-IN-1
产品货号 : M32961
cas no: 2095156-13-9
HSL-IN-1 (compound 24b) 是一种有效且具有口服活性的激素敏感脂肪酶 (HSL) 抑制剂 (IC50=2 nM),显著降低了活性代谢物负荷。 -
Isolicoflavonol
产品货号 : M29169
cas no: 94805-83-1
异黄酮醇可抑制人羧酸酯酶 2 (hCES2A),而人羧酸酯酶 2 (hCES2A) 是改善伊立替康引发的肠道毒性的关键靶标,伊立替康会导致 50%-80% 接受该抗癌药物的患者出现严重腹泻。 -
MAGL-IN-5
产品货号 : M28991
cas no: 359714-55-9
MAGL-IN-5 是一种非选择性脂肪酶抑制剂。