DPP
DPP-4 is a catalytic glycoprotein which releases a dipeptide from oligopeptides by cleaving the peptides between the second and the third amino acids from the N-terminal end provided that the second amino acid is alanine or proline. DPP-4 (or CD26 as it is also called) was later demonstrated to be expressed in several cell types, such as hepatocytes, glomerular cells, kidney tubular cells and endothelial cells as well as in islet endocrine cells. DPP-4 is a protein which consists of 766 amino acids. DPP-4 is a functional unit consisting of two identical DPP-4 proteins attached to each other forming a dimer. The organization of the dimer is such that the catalytic sites of the two DPP-4 molecules are located in close proximity to each other. Together the two catalytic sites form a pocket which has a high catalytic activity.
References
1.Ahrén B. Front Endocrinol (Lausanne). 2019 Jun 19;10:376.
References
1.Ahrén B. Front Endocrinol (Lausanne). 2019 Jun 19;10:376.
Metabolic Enzyme/Protease
11β-HSD(15)
15-PGDH(1)
ACC(10)
ACE(11)
AChE(29)
Adenylate Cyclase(12)
ALDH(14)
Aldose Reductase(5)
Aminopeptidase(17)
BACE(18)
Casein Kinase(41)
CAT(5)
Cathepsin(9)
CETP(10)
COMT(2)
CPG2(1)
CYPs(6)
Decarboxylase(3)
Dehydrogenase(87)
DGAT(4)
Dopamine beta-hydroxylase(2)
DPP(27)
Elastase(6)
FAAH(19)
Factor Xa(24)
Fatty Acid Synthase(16)
Ftase(2)
FXR(22)
Glucokinase(1)
GSNOR(2)
Guanylate Cyclase(9)
HMGCR(17)
IDH(7)
IDO(19)
IMPDH(2)
LDH(2)
LDL(5)
Lipase(13)
Lipid(9)
MAGL(3)
MAO(52)
MMP(53)
NAMPT(7)
Neprilysin(6)
Other Targets(9)
P450(87)
PAI-1(7)
Phosphatase(51)
Phospholipase(42)
PPAR(86)
Protein Phosphatase/PTP(6)
Renin(8)
Retinoid Receptor(23)
SCD(6)
Steroid Sulfatase (STS)(2)
Thioredoxin(1)
TPH(5)
Transferase(24)
Vitamin(39)
Xanthine Oxidase (XAO)(6)
DPP
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Azaleatin
产品货号 : M29097
cas no: 529-51-1
Azaleatin 是杜鹃花的天然产物。 Azaleatin 是一种二肽基肽酶-IV 抑制剂。 Azaleatin 可用于 2 型糖尿病和肥胖研究。 -
Diprotin A
产品货号 : M27813
cas no: 90614-48-5
Diprotin A (Ile-Pro-Ile) 是二肽基肽酶 IV (DPP-IV) 的抑制剂。 -
Sitagliptin phosphate
产品货号 : M27711
cas no: 654671-78-0
Sitagliptin 磷酸盐是一种二肽基肽酶 4 (DPP4) 抑制剂。 -
DPP-IV-IN-2
产品货号 : M26242
cas no: 136259-18-2
DPP-IV-IN-2 是 DP8/9 和二肽基肽酶 IV 的抑制剂(IC50:0.1 和 0.95 μM)。 -
Saikogenin A
产品货号 : M24472
cas no: 5092-09-1
Saikogenin A 是一种二肽基肽酶 4 抑制剂。