Retinoid Receptor
Retinoids are a class of chemical compounds, which include active metabolites of vitamin A (retinol) as well as a diverse array of synthetic derivatives. Retinoids modulate a wide variety of cellular processes, including proliferation, differentiation, homeostasis, malignant transformation, and apoptosis.The retinoic acid receptor (RAR) and retinoid X receptor (RXR) mediate the cellular effects of retinoids (derivatives of vitamin A). Both RAR and RXR signaling events are implicated in hippocampal synaptic plasticity. Furthermore, retinoids can interact with calcium signaling during homeostatic plasticity.
References
1.Anita L. Sabichi et al. Clinical Cancer Research. October 2003 Volume 9, Issue 12
References
1.Anita L. Sabichi et al. Clinical Cancer Research. October 2003 Volume 9, Issue 12
Metabolic Enzyme/Protease
11β-HSD(15)
15-PGDH(1)
ACC(10)
ACE(15)
AChE(47)
Adenylate Cyclase(12)
ALDH(14)
Aldose Reductase(5)
Aminopeptidase(19)
BACE(19)
Casein Kinase(51)
CAT(5)
Cathepsin(9)
CETP(13)
COMT(2)
CPG2(1)
CYPs(6)
Decarboxylase(3)
Dehydrogenase(131)
DGAT(4)
Dopamine beta-hydroxylase(2)
DPP(32)
Elastase(6)
FAAH(28)
Factor Xa(31)
Fatty Acid Synthase(17)
Ftase(2)
FXR(26)
Glucokinase(1)
GSNOR(2)
Guanylate Cyclase(13)
HMGCR(17)
IDH(7)
IDO(20)
IMPDH(2)
LDH(2)
LDL(8)
Lipase(17)
Lipid(12)
MAGL(6)
MAO(72)
MMP(78)
NAMPT(12)
Neprilysin(7)
Other Targets(10)
P450(112)
PAI-1(9)
Phosphatase(95)
Phospholipase(65)
PPAR(115)
Protein Phosphatase/PTP(6)
Renin(8)
Retinoid Receptor(37)
SCD(6)
Steroid Sulfatase (STS)(2)
Thioredoxin(1)
TPH(5)
Transferase(37)
Vitamin(44)
Xanthine Oxidase (XAO)(11)
Retinoid Receptor
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KCL-286
产品货号 : M37200
cas no: 1952276-71-9
KCL-286 是一种口服有效的视黄酸受体 (RAR/RXR) β2 激动剂,对脊髓损伤 (SCI) 有改善作用。 -
Mofarotene
产品货号 : M36197
cas no: 125533-88-2
Mofarotene (Ro-40-8757) is a small molecule compound that shows considerable antitumor activity in many cancer cell lines and can be used for the treatment of tumors and respiratory diseases.Mofarotene is a retinoic acid analog that binds to and activates retinoic acid receptors (RARs), which alters the expression of certain genes, leading to reduced cell differentiation and cell proliferation in susceptible cells. -
Ro 41-5253
产品货号 : M34401
cas no: 144092-31-9
Ro 41-5253 是一种具有口服活性的选择性维甲酸受体 RARα 拮抗剂。Ro 41-5253 可以与 RARα 结合而不诱导转录或影响 RAR/RXR 异二聚化和 DNA 结合。Ro 415253 可抑制癌细胞增殖并诱导细胞凋亡 (apoptosis),具有抗肿瘤活性。 -
BMS641
产品货号 : M34187
cas no: 369364-50-1
BMS641 (BMS-209641) 是一种选择性的 RARβ 激动剂。BMS641 对 RARβ (Kd,2.5 nM) 的亲和力比 RARα (Kd,225 nM) 或 RARγ (Kd, 223 nM) 的亲和力高100倍。 -
K-8012
产品货号 : M33994
cas no: 1346513-17-4
K-8012 is a modulator of the N-terminally truncated RXRα and improves anticancer activities in an RXRα-dependent manner.