GLUT
Glucose is the primary energy source for life on earth. It also serves as an important precursor for biomolecule synthesis, and plays an important role in cell signaling. GLUTs are ubiquitously distributed and catalyze facilitative diffusion of glucose down its concentration gradient. GLUTs are encoded by the SLC2 genes. Fourteen members have been identified in human, which are classified into three classes. GLUT1 is one of the first membrane transporters to be cloned, GLUT2 is the major glucose transporter in hepatocytes and intestine and exhibits several distinctive characteristics compared to the other three GLUTs, GLUT3 is mainly expressed in neurons, thereby also referred to as the “neuronal glucose transporter.”GLUT4 is highly expressed in adipose tissues and skeletal muscles.
References
1.Dong Deng,et al. Protein Sci. 2016 Mar; 25(3): 546–558.
References
1.Dong Deng,et al. Protein Sci. 2016 Mar; 25(3): 546–558.
Membrane Transporter/Ion Channel
AMPK(58)
ASBT Transporter(6)
BCRP(10)
Beta Amyloid(69)
Carbonic Anhydrase(40)
Chloride Channel(34)
CRAC Channel(0)
CRM1(5)
Exportin-1(5)
FABP(6)
GAT(62)
GLUT(5)
Glutamate Transporter(1)
GlyT(13)
HCN Channel(5)
iGluR(52)
Monoamine Transporter(26)
Monocarboxylate Transporter(12)
MTP(1)
nAChR(5)
NADPH(35)
Na-K-ATPase(2)
NKCC(4)
NMDAR(64)
OCT(4)
Other Targets(13)
P2X Receptor(23)
P-glycoprotein(14)
Potassium Channel(0)
Proton Pump(38)
Sodium Channel(147)
TRP/TRPV Channel(115)
URAT1(1)
GLUT
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STF-31
产品货号 : M15774
cas no: 724741-75-7
一种选择性 GLUT1 抑制剂,不与其他葡萄糖转运蛋白结合。 -
Fasentin
产品货号 : M14350
cas no: 392721-37-8
Fasentin 是一种新型葡萄糖摄取 (GLUT) 抑制剂,可使癌细胞对 FAS 诱导的细胞死亡敏感,与 GLUT1 相比,优先抑制 GLUT4 (IC50=68 uM)。 -
BAY-876
产品货号 : M12727
cas no: 1799753-84-6
一种有效的、高选择性的、口服生物可利用的 GLUT1 抑制剂,IC50 为 2 nM;对 GLUT2、GLUT3 和 GLUT4 显示 >100 倍的选择性。 -
WZB117
产品货号 : M10853
cas no: 1223397-11-2
WZB117 (WZB-117) 是葡萄糖转运蛋白 1 (GLUT1) 的小分子抑制剂。 -
GLUT4-IN-17
产品货号 : M10271
cas no: 1061081-61-5
一种有效的选择性葡萄糖转运蛋白 4 (GLUT4) 抑制剂,IC450 为 10.8 uM,可抑制 MM 细胞增殖。