Carbonic Anhydrase
Carbonic anhydrase is a zinc metalloenzyme found in animals, plants, algae, and prokaryotes. This enzyme catalyzes the hydration reaction of carbon dioxide (CO2) into bicarbonate (HCO3−) and protons (H+), playing a crucial role in different physiological processes. Five carbonic anhydrase families, referred to as α, β, γ, δ, and ζ have been identified in animals and plants. The structure of the α-carbonic anhydrase family is characterized by three histidine residues that bind the zinc cofactor, and a proton shuttling residue at the entrance of the active site is responsible for converting a zinc-bound water molecule to a hydroxide ion.In animals, carbonic anhydrase is present in many different tissues and is involved in numerous physiological processes, including osmoregulation, ion transport, acid–base regulation, respiration, and calcification.
In algae and plants, this enzyme plays an important role in photosynthesis.Aquatic organisms have high concentrations of carbonic anhydrase in this tissue, where this enzyme plays an essential role in maintaining constant levels of osmolytes, such as Na+ and Cl−, that are important for cell function.The mammalian lung has carbonic anhydrase associated with the endothelial membrane that is exposed to plasma, and the kidney tubule also has carbonic anhydrase present on the luminal brush borders. Carbonic anhydrase is also important for mitochondrial metabolism as the HCO3− resulting from this enzyme activity provides an intra mitochondrial counter-anion facilitating Ca2+ accumulation in the mitochondrial matrix in the form of CaCO3. Carbonic anhydrase plays an important role in biological calcification, a fundamental process performed by a great number of marine invertebrates. This process occurs at the interface between organic and mineral tissues, with the formation of an organic matrix that acts as the deposition center of CaCO3 crystals, termed as the calcification site.
References
1.Yuri Dornelles Zebral,et al. Int J Mol Sci. 2019 Jun; 20(12): 3092.
In algae and plants, this enzyme plays an important role in photosynthesis.Aquatic organisms have high concentrations of carbonic anhydrase in this tissue, where this enzyme plays an essential role in maintaining constant levels of osmolytes, such as Na+ and Cl−, that are important for cell function.The mammalian lung has carbonic anhydrase associated with the endothelial membrane that is exposed to plasma, and the kidney tubule also has carbonic anhydrase present on the luminal brush borders. Carbonic anhydrase is also important for mitochondrial metabolism as the HCO3− resulting from this enzyme activity provides an intra mitochondrial counter-anion facilitating Ca2+ accumulation in the mitochondrial matrix in the form of CaCO3. Carbonic anhydrase plays an important role in biological calcification, a fundamental process performed by a great number of marine invertebrates. This process occurs at the interface between organic and mineral tissues, with the formation of an organic matrix that acts as the deposition center of CaCO3 crystals, termed as the calcification site.
References
1.Yuri Dornelles Zebral,et al. Int J Mol Sci. 2019 Jun; 20(12): 3092.
Membrane Transporter/Ion Channel
AMPK(58)
ASBT Transporter(6)
BCRP(10)
Beta Amyloid(69)
Carbonic Anhydrase(40)
Chloride Channel(34)
CRAC Channel(0)
CRM1(5)
Exportin-1(5)
FABP(6)
GAT(63)
GLUT(5)
Glutamate Transporter(1)
GlyT(13)
HCN Channel(5)
iGluR(52)
Monoamine Transporter(26)
Monocarboxylate Transporter(12)
MTP(1)
nAChR(5)
NADPH(35)
Na-K-ATPase(2)
NKCC(4)
NMDAR(65)
OCT(4)
Other Targets(13)
P2X Receptor(23)
P-glycoprotein(14)
Potassium Channel(0)
Proton Pump(38)
Sodium Channel(147)
TRP/TRPV Channel(115)
URAT1(1)
Carbonic Anhydrase
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hCAI/II/IV-IN-28
产品货号 : M37274
cas no: 78659-11-7
hCAI/II/IV-IN-28(WAY-638358) is a potent carbonic anhydrase inhibitor with potential anticonvulsant activity. -
Enpp/Carbonic?anhydrase-IN-2
产品货号 : M37002
cas no: 2883495-39-2
Enpp/Carbonic anhydrase-IN-2 (compound 1i) 是一种有效的 Enpp 和 carbonic anhydrase 抑制剂,对 NPP1、NPP2、NPP3、CA-IX, CA-XII 的 IC50 值分别 1.13、 1.07、 0.74、 0.33、 0.68。Enpp/Carbonic anhydrase-IN-2 对癌细胞具有抗增殖活性,对正常细胞具有低细胞毒性。Enpp/Carbonic anhydrase-IN-2 诱导细胞凋亡 (Apoptosis)。 -
Histone acetyltransferase p300 Inhibitor 4c
产品货号 : M36950
cas no: 2103-99-3
Histone acetyltransferase p300 Inhibitor 4c is a 2-aminothiazole derivative. Histone acetyltransferase p300 Inhibitor 4c inhibited hCA I, hCA II, AChE and BChE with Ki values of 0.008 ± 0.001, 0.124 ± 0.017, 0.129 ± 0.030 and 0.083 ± 0.041 μM. 0.017, 0.129 ± 0.030 and 0.083 ± 0.041 μM. -
Girentuximab
产品货号 : M36663
cas no: 916138-87-9
Girentuximab (G250) 是一种嵌合单克隆抗体,可与碳酸酐酶 IX (CAIX) 结合,碳酸酐酶 IX 是一种在透明细胞肾细胞癌 (ccRCC) 中广泛表达的细胞表面糖蛋白。 -
hCAII-IN-9
产品货号 : M36504
cas no: 2878477-18-8
hCAII-IN-9 是一种强效的碳酸酐酶抑制剂,IC50 分别为 1.18 μM (hCA II), 0.17 μM (hCA IX), and 2.99 μM (hCA XII)。hCAII-IN-9 没有血脑屏障透过性。