021-51111890/在线客服
购物车（0）
sales@molnova.cn
  • 咨询热线
    客服服务热线 13671568941/15317326293
  • 在线咨询
    963389683
  • 微信客服
    微信客服
  • 公众号
    扫码关注公众号
首页- 产品 - Membrane Transporter/Ion Channel - GlyT

GlyT

GlyTs mediate the uptake of glycine from the extracellular space into the cytosol. They belong to a large family of NaC/ClK-dependent transporter proteins, which includes transporters for monoamines (serotonin, norepinephrine and dopamine) and the inhibitory neurotransmitter g-aminobutyric acid (GABA). These polytopic membrane proteins share a common transmembrane topology with 12 transmembrane domains (TMDs) connected by six extracellular and five intracellular loops.  Both GlyTs exist in multiple splice variants: three GlyT2 isoforms (a, b, c) differ in the N-terminal region, whereas three N-terminal (a, b, c) and two C-terminal (d, e) exons have been reported to generate different variants of GlyT1.  The transporters GLYTla, GLYTlb and GLYTlc have been isolated from the CNS of both rodents and humans. Two isoforms of the GLYT2 gene product have been reported and have been named GLYT2a and GLYT2b. The uptake of glycine mediated by GlyTs is energetically coupled to the transmembrane sodium gradient maintained by the NaC/KC-ATPase. Pharmacological evidence indicates that GLYT 1 transports glycine in the cerebral cortex, but that in the cerebellum, it shares this function with GLYT2.

References

1.Eulenburg V, et al. Trends Biochem Sci. 2005;30(6):325–333.
2.Tunnicliff G. J Biomed Sci. 2003;10(1):30–36.

Membrane Transporter/Ion Channel

AMPK(58) ASBT Transporter(6) BCRP(10) Beta Amyloid(69) Carbonic Anhydrase(40) Chloride Channel(34) CRAC Channel(0) CRM1(5) Exportin-1(5) FABP(6) GAT(62) GLUT(5) Glutamate Transporter(1) GlyT(13) HCN Channel(5) iGluR(52) Monoamine Transporter(26) Monocarboxylate Transporter(12) MTP(1) nAChR(5) NADPH(35) Na-K-ATPase(2) NKCC(4) NMDAR(64) OCT(4) Other Targets(13) P2X Receptor(23) P-glycoprotein(14) Potassium Channel(0) Proton Pump(38) Sodium Channel(147) TRP/TRPV Channel(115) URAT1(1)

GlyT

登录 注册