FABP
FABPs, a family of 14-15 kDa proteins, act as chaperonins of FFA and bind with high affinity to hydrophobic ligands such as saturated and unsaturated long-chain fatty acids and eicosanoids. With the assistance of a variety of proteins, FABPs, such as FABP2, FABP3, FABP4 and FABP5 can transfer FFA to the target areas in order to regulate the oxidation power and further esterification of FFA. These target areas include the endoplasmic reticulum, mitochondria, peroxide multiplication enzyme and cell nucleus. Z-protein in rat liver was the first report ever to give the complete amino acid sequence of a fatty acid binding protein (FABP). So far 9 different FABPs, with tissue-specific distribution, have been identified: L (liver), I (intestinal), H (muscle and heart), A (adipocyte), E (epidermal), Il (ileal), B (brain), M (myelin) and T (testis). One group of the transcription factors cooperating with FABPs is the PPAR family. PPAR is a key transcription factor in preadipocyte differentiation. FABP also have an effect on ligand-dependent transactivation of PPARs, i.e. A-FABP and E-FABP selectively interact with PPAR and PPAR , respectively and L-FABP with PPAR and PPAR.
References
1.Wang YT, et al. Expert Opin Ther Pat. 2016;26(7):767–776.
2.Ono T. Mol Cell Biochem. 2005;277(1-2):1–6.
3.Chmurzyńska A. J Appl Genet. 2006;47(1):39–48.
References
1.Wang YT, et al. Expert Opin Ther Pat. 2016;26(7):767–776.
2.Ono T. Mol Cell Biochem. 2005;277(1-2):1–6.
3.Chmurzyńska A. J Appl Genet. 2006;47(1):39–48.
Membrane Transporter/Ion Channel
AMPK(58)
ASBT Transporter(6)
BCRP(10)
Beta Amyloid(69)
Carbonic Anhydrase(40)
Chloride Channel(34)
CRAC Channel(0)
CRM1(5)
Exportin-1(5)
FABP(6)
GAT(62)
GLUT(5)
Glutamate Transporter(1)
GlyT(13)
HCN Channel(5)
iGluR(52)
Monoamine Transporter(26)
Monocarboxylate Transporter(12)
MTP(1)
nAChR(5)
NADPH(35)
Na-K-ATPase(2)
NKCC(4)
NMDAR(64)
OCT(4)
Other Targets(13)
P2X Receptor(23)
P-glycoprotein(14)
Potassium Channel(0)
Proton Pump(38)
Sodium Channel(147)
TRP/TRPV Channel(115)
URAT1(1)
FABP
-
STK-15
产品货号 : M36261
cas no: 844651-66-7
STK-15 is a candidate for use as an inhibitor of fatty acid binding protein 5 (FABP5). -
FABPs ligand 6
产品货号 : M35676
cas no: 2988135-14-2
FABPs ligand 6 (MF6) 是一种 FABP5 和 FABP7 抑制剂,KD 值分别为 874 nM 和 20 nM。FABPs ligand 6 可用于多发性硬化症的研究。 -
HTS 01037
产品货号 : M15609
cas no: 682741-29-3
HTS01037 是脂肪细胞脂肪酸结合蛋白 (A-FABP/aP2) 的高效配体,Ki 为 0.67 uM。 -
BMS-309403
产品货号 : M13930
cas no: 300657-03-8
一种有效、选择性、细胞渗透性和口服活性的 FABP4(脂肪酸结合蛋白 4)抑制剂,Ki 小于 2 nM。 -
SBFI-26
产品货号 : M12179
cas no: 1541209-75-9
SBFI-26 (SBFI26) 是一种表皮和大脑特异性 FABP5 和 FABP7 的小分子抑制剂,可有效增强 anandamide 信号传导。