NADPH
Nicotinamide Adenine Dinucleotide(NAD), reduced nicotinamide adenine dinucleotide (NADH), nicotinamide adenine dinucleotide phosphate (NADP), and reduced nicotinamide adenine dinucleotide phosphate (NADPH) have been known as classic molecules involving in energy metabolism, reductive biosynthesis, and antioxidation. Structurally NADP is identical to NAD except for the additional 2’ phosphate on the adenosine ribose moieties of NADP. However, NAD (including NAD and NADH) are mainly used by the enzymes that catalyze substrate oxidation, while NADP (including NADP and NADPH) are mainly used by the enzymes that catalyze substrate reduction. Recent studies have indicated pivotal roles of NAD-dependent histone deacetylases (i.e., sirtuins) in aging; b) poly(ADP-ribose) polymerase-1 (PARP-1)—-a major NAD-consuming enzyme—-appears to mediate oxidative cell death under many conditions; c) cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP)—-two endogeneous molecules generated from NAD—-are key signaling molecules mobilizing intracellular calcium stores; and d) NADPH oxidase is a major generator of reactive oxygen species (ROS) in both immunological reactions and multiple diseases. NAD may affect gene expression through several pathways.
NADH mediates the activity of the corepressor carboxyl-terminal binding protein—-a transcriptional factor important for cell cycle regulation, development, and transformation and NADH also modulates the activities of Clock:BMAL1 and NPAS2:BMAL1 that are heterodimeric transcription factors controlling circadian clock-associated gene expression. Selective inhibition of NAD synthesis has been shown to induce apoptosis of tumor cells. Because PARP-1 plays critical roles in regulating DNA repair, genomic stability, and cell cycle progression, many studies have been conducted to determine the roles of PARP-1 in carcinogenesis. Because NAD and NADP can profoundly affect cell death and various biological processes including gene expression and signal transduction, future studies may further elucidate important roles of NAD and NADP in carcinogenesis and cancer treatment.
NADH mediates the activity of the corepressor carboxyl-terminal binding protein—-a transcriptional factor important for cell cycle regulation, development, and transformation and NADH also modulates the activities of Clock:BMAL1 and NPAS2:BMAL1 that are heterodimeric transcription factors controlling circadian clock-associated gene expression. Selective inhibition of NAD synthesis has been shown to induce apoptosis of tumor cells. Because PARP-1 plays critical roles in regulating DNA repair, genomic stability, and cell cycle progression, many studies have been conducted to determine the roles of PARP-1 in carcinogenesis. Because NAD and NADP can profoundly affect cell death and various biological processes including gene expression and signal transduction, future studies may further elucidate important roles of NAD and NADP in carcinogenesis and cancer treatment.
Membrane Transporter/Ion Channel
AMPK(58)
ASBT Transporter(6)
BCRP(10)
Beta Amyloid(69)
Carbonic Anhydrase(40)
Chloride Channel(34)
CRAC Channel(0)
CRM1(5)
Exportin-1(5)
FABP(6)
GAT(63)
GLUT(5)
Glutamate Transporter(1)
GlyT(13)
HCN Channel(5)
iGluR(52)
Monoamine Transporter(26)
Monocarboxylate Transporter(12)
MTP(1)
nAChR(5)
NADPH(35)
Na-K-ATPase(2)
NKCC(4)
NMDAR(65)
OCT(4)
Other Targets(13)
P2X Receptor(23)
P-glycoprotein(14)
Potassium Channel(0)
Proton Pump(38)
Sodium Channel(147)
TRP/TRPV Channel(115)
URAT1(1)
NADPH
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Aucuparin
产品货号 : M37763
cas no: 3687-28-3
Aucuparin (2,6-dimethoxy-4-phenylphenol) is a plant antibiotic with anti-inflammatory activity. Aucuparin inhibited pulmonary fibrosis in mouse models induced by bleomycin (BLM). ABTS and FRAP showed clear scavenging activity. Aucuparin inhibited superoxide production of human neutrophils induced by fmlp, and its IC50 was 17.0μM. -
NecroX-7 B
产品货号 : M37704
cas no: 1120332-55-9
NecroX-7 是一种有效的自由基清除剂,是一种 HMGB1 (高迁移率族蛋白 1) 抑制剂。NecroX-7 可以作为对乙酰氨基酚毒性的解毒剂。NecroX-7 通过抑制缺血/再灌注损伤中 HMGB1 的释放发挥保护作用。NecroX-7 抑制 HMGB1 诱导的 TNF 和 IL-6 的释放,以及 TLR-4 和晚期糖基化终产物受体的表达。NecroX-7 可用于移植物抗宿主病 (GVHD) 研究。 -
gp91 ds-tat
产品货号 : M37261
cas no: 329902-61-6
gp91 ds-tat 是一种有生物活性的肽。(NADPH氧化酶组装肽抑制剂) -
Casein kinase 1δ-IN-9
产品货号 : M35815
cas no: 854355-54-7
Casein kinase 1δ-IN-9 (compound 737) 是一种有效的酪蛋白激酶 1δ (CK1δ/CK15) 抑制剂。Casein kinase 1δ-IN-9 可用于阿尔茨海默病等神经退行性疾病的研究。 -
HTS07545
产品货号 : M35541
cas no: 118666-03-8
HTS07545 是一种有效的硫化物:醌氧化还原酶 (SQOR) 抑制剂,IC50 为 30 nM。HTS07545 降低硫化氢 (H2S) 的分解速率。HTS07545 可用于心力衰竭研究。