STF-31

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种选择性 GLUT1 抑制剂，不与其他葡萄糖转运蛋白结合。

A selective GLUT1 inhibitor that does not bind to other glucose transporters; selectively kills RCCs by specifically targeting glucose uptake through GLUT1 and exploiting the unique dependence of these cells on GLUT1 for survival; also inhibits the enzymatic activity of NAMPT in a biochemical assay in vitro.

Cell Viability Assay Cell Line:Wild-type RCC4 cells (RCC4/VHL)and RCC4 cells without VHL Concentration:0.01, 0.1, 1, 10 μM Incubation Time:10 days Result:Reduced viability of RCC4 cells without VHL in a concentration-dependent manner when compared to their wild-type counterparts.

Animal Model:Twelve-week old C57BL/6J and CX3CR1gfp/+ miceDosage:10 mg/kg Administration:I.p. injections; twice daily for 2 days, followed by once daily for another 3 days Result:Improved photoreceptor survival and reduced microglial activation of CX3CR1gfp/+ mice, and not induced any C57BL/6J mice retinal cell death.

STF31 | STF-31 | STF 31

Membrane Transporter/Ion Channel

GLUT

GLUT1

Cancer

——

724741-75-7

423.5279

C23H25N3O3S

>98% (HPLC)

DMSO: ≥ 34 mg/mL

O=C(NC1=CC=CN=C1)C2=CC=C(CNS(=O)(C3=CC=C(C(C)(C)C)C=C3)=O)C=C2

Benzamide, 4-[[[[4-(1,1-dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinyl-

(-20℃)

With Ice Pack

≥ 2 years