Lipoxygenase
as linoleic acid and arachidonic acid. Lipoxygenases (LOXs) catalyze the oxygenation of polyunsaturated fatty acids such as arachidonic acid and linoleic acid. The oxygenated lipids initiate subsequent biological reactions, activate cellular signaling mechanisms through specific cell surface receptors, or are further metabolized into potent lipid mediators. LOX can be found not only in mammals, but also in plants. Historically, biochemical characterizations have been performed mainly on soybean LOX isoforms. While the overall structure of mammalian LOX enzymes seems to be similar, each isoform has unique properties, such as substrate specificity.
LOX enzymes require a lag period for the activation of enzymes from an inactive ferrous form to an active ferric form by either molecular oxygen or lipid hydroperoxides. LOX enzymatic activity can be inhibited by phenolic antioxidants such as nordihydroguaiaretic acid and caffeic acid, suggesting a beneficial role of dietary polyphenol intake. The physiological roles of LOX enzymes have been studied extensively, due to the close link between them and various diseases. Apparently, the best characterized example includes the relation between 5-LOX and asthma, because cysteinyl leukotriene receptor 1, a GPCR activated by leukotrienes produced by 5-LOX, is widely expressed on bronchiolar smooth muscle cells. Genetically, both ALOX12B and ALOXE3 play a critical role in the development of ichthyosis through TEWL. In humans, some mutations in ALOX12 are found in tumor cells, suggesting this isoform might have anti-tumor effect. An increased expression of LOX enzymes in response to Th2 cytokines has been well established.
References
1.Mashima R, et al. Redox Biol. 2015;6:297–310.
LOX enzymes require a lag period for the activation of enzymes from an inactive ferrous form to an active ferric form by either molecular oxygen or lipid hydroperoxides. LOX enzymatic activity can be inhibited by phenolic antioxidants such as nordihydroguaiaretic acid and caffeic acid, suggesting a beneficial role of dietary polyphenol intake. The physiological roles of LOX enzymes have been studied extensively, due to the close link between them and various diseases. Apparently, the best characterized example includes the relation between 5-LOX and asthma, because cysteinyl leukotriene receptor 1, a GPCR activated by leukotrienes produced by 5-LOX, is widely expressed on bronchiolar smooth muscle cells. Genetically, both ALOX12B and ALOXE3 play a critical role in the development of ichthyosis through TEWL. In humans, some mutations in ALOX12 are found in tumor cells, suggesting this isoform might have anti-tumor effect. An increased expression of LOX enzymes in response to Th2 cytokines has been well established.
References
1.Mashima R, et al. Redox Biol. 2015;6:297–310.
Immunology/Inflammation
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Lipoxygenase
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12R-LOX-IN-2
产品货号 : M37042
cas no: 3026677-37-9
12R-LOX-IN-2 is an inhibitor of 12R-lipoxygenase (12R-LOX).12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and inhibits colony formation.12R-LOX-IN-2 also decreases the protein level of Ki67 and the mRNA expression of IL-17A in IMQ-induced cells. 12R-LOX-IN-2 may be useful in the study of psoriasis and other skin-associated inflammatory diseases. -
5-LOX-IN-2
产品货号 : M36938
cas no: 179691-97-5
5-LOX-IN-2 是 一种 5-脂氧合酶抑制剂 (5-LOX ),IC50 为 0.33 μM,以剂量依赖的方式抑制 5-LOX。5-LOX-IN-2 可降低肾癌细胞的细胞活性并诱导凋亡 (apoptosis),可用于癌症研究。 -
KKII5
产品货号 : M36849
cas no: 6381-55-1
KKII5 是一种有效的脂氧合酶 LOX-1 抑制剂,IC50 为 19 μM。KKII5 抑制脂质过氧化。 -
ER-34122
产品货号 : M36331
cas no: 179325-62-3
ER-34122, a novel orally available dual 5-lipoxygenase/cyclooxygenase inhibitor, exhibits potent anti-inflammatory activity in an arachidonic acid-induced ear inflammation model. -
ZD-2138
产品货号 : M36250
cas no: 140841-32-3
ZD-2138 is a potent and selective specific inhibitor of 5-lipoxygenase (5-LOX) that inhibits allergen-induced pulmonary bronchoconstriction and reduces neurally-induced fast-acting kallikrein-ergic constriction of isolated airways in guinea pigs.ZD-2138 can be used for the treatment of asthma disease.