5-LOX-IN-2

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

5-LOX-IN-2 是 一种 5-脂氧合酶抑制剂 (5-LOX )，IC50 为 0.33 μM，以剂量依赖的方式抑制 5-LOX。5-LOX-IN-2 可降低肾癌细胞的细胞活性并诱导凋亡 (apoptosis)，可用于癌症研究。

5-LOX-IN-2, an inhibitor of 5-lipoxygenase (5-LOX) with an IC50 of 0.33 μM, inhibits 5-LOX in a dose-dependent manner . 5-LOX-IN-2, reduces the cell viability of renal cancer cells and induces apoptosis, can be used for cancer research.

Cell Viability AssayCell Line:RCC4, RCC10, 786.0 cells Concentration:0-100 μM Incubation Time:4 days Result:Reduced the cell viability of renal cancer cells and was more selective toward RCC4 and 786.0 cells which are deficient for the Von Hippel-Lindau (VHL) tumor suppressor gene.Western Blot Analysis Cell Line:RCC4, RCC10, 786.0 cells Concentration:0-10 μM Incubation Time:24 hours Result:Increased in LC3B and p62 expression, blocked of the autophagic flux in RCC4 cells. Stimulated in a dose ependent manner the cleavage of pro-caspase-3 only in the RCC4 cells which lack the VHL tumor suppressor.

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Immunology/Inflammation

Lipoxygenase

Lipoxygenase | Apoptosis

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179691-97-5

284.31

C17H16O4

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (351.73 mM; 超声助溶 )

C(=C/C(OCCC1=CC=CC=C1)=O)\C2=C(O)C=CC(O)=C2

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(-20℃)

With Ice Pack

≥ 2 years