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IRAK

The interleukin receptor-associated kinase (IRAK) family are involved in regulating Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways.IL-1/TLR signalling pathways and the IRAK family are critical in anti-pathogen responses, inflammation and autoimmunity. The family comprises of four members, IRAK-1, IRAK-2, IRAK-M (IRAK-3) and IRAK-4, and has a role in both positive and negative regulation of signal transduction.Two are active kinases, IRAK-1 and IRAK-4, and two are inactive, IRAK-2 and IRAK-M, but all regulate the nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) pathways.IRAK family members have been implicated in certain disease models including human immunodeficiencies.

References

1.Flannery S, Bowie AG.Biochem Pharmacol. 2010 Dec 15;80(12):1981-91. doi: 10.1016/j.bcp.2010.06.020.

Immunology/Inflammation

Amino Acids and Derivatives(27) Antiviral(34) CD110(2) Cell wall(3) Complement System(20) FLAP(9) Hydroxylase(10) Interferon Receptor(3) IRAK(18) IκB kinase (IKK)(36) Lipoxygenase(30) LTR(6) MyD88(5) NOS(67) PD-1/PD-L1(18) PGE synthase(13) RLR(4) ROS(44) Scavenger Receptor(2) SphK(3) STING(21) TLR(52)