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IRAK
The interleukin receptor-associated kinase (IRAK) family are involved in regulating Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways.IL-1/TLR signalling pathways and the IRAK family are critical in anti-pathogen responses, inflammation and autoimmunity. The family comprises of four members, IRAK-1, IRAK-2, IRAK-M (IRAK-3) and IRAK-4, and has a role in both positive and negative regulation of signal transduction.Two are active kinases, IRAK-1 and IRAK-4, and two are inactive, IRAK-2 and IRAK-M, but all regulate the nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) pathways.IRAK family members have been implicated in certain disease models including human immunodeficiencies.
References
1.Flannery S, Bowie AG.Biochem Pharmacol. 2010 Dec 15;80(12):1981-91. doi: 10.1016/j.bcp.2010.06.020.
References
1.Flannery S, Bowie AG.Biochem Pharmacol. 2010 Dec 15;80(12):1981-91. doi: 10.1016/j.bcp.2010.06.020.
Immunology/Inflammation
Amino Acids and Derivatives(42)
Antiviral(77)
CD110(2)
Cell wall(0)
Complement System(33)
FLAP(9)
Hydroxylase(14)
Interferon Receptor(6)
IRAK(24)
IκB kinase (IKK)(41)
Lipoxygenase(53)
LTR(13)
MyD88(6)
NOS(85)
PD-1/PD-L1(38)
PGE synthase(14)
RLR(4)
ROS(61)
Scavenger Receptor(2)
SphK(3)
STING(27)
TLR(68)
IRAK
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GLPG2534
产品货号 : M36623
cas no: 2095615-97-5
GLPG2534 是一种具有口服活性的选择性 IRAK4 抑制剂，对人和小鼠 IRAK4 的 IC50 值为 6.4 nM 和 3.5 nM。GLPG2534可用于炎症性皮肤病的研究。
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IRAK4-IN-8
产品货号 : M35718
cas no: 2033070-97-0
IRAK4-IN-8 (VI-177) 是一种有效的 IRAK4 抑制剂。
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IRAK4-IN-20
产品货号 : M35663
cas no: 1931994-80-7
IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM). IRAK4-IN-20, which has anti-inflammatory, antitumor and anticancer effects, is often used to treat acute respiratory distress syndrome (ARDS).
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Edecesertib
产品货号 : M35644
cas no: 2408839-73-4
Edecesertib (GS-5718) 是一种具有选择性且口服有效的 IRAK-4 抑制剂。Edecessertib 具有抗炎活性。Edecessertib 可用于类风湿性关节炎 (RA) 和红斑狼疮 (LE) 的研究。
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IRAK4-IN-10
产品货号 : M35604
cas no: 2681278-09-9
IRAK4-IN-10 (compound 75) 是一种有效的 IRAK4 抑制剂，IC50 为 1.5 nM。IRAK4-IN-10 阻断 MyD88 依赖的信号通路。IRAK4-IN-10 具有研究炎症性疾病、自身免疫性疾病和癌症的潜力。
