STING
STING (Stimulator of Interferon Genes, also known as TMEM173, MITA, ERIS, and MPYS) is an adapter transmembrane protein that resides in the endoplasmic reticulum (ER). In eukaryotic cells, activation of STING occurs when double stranded DNA gains access to the cytosol. This pathway was originally uncovered in search for a mechanism by which DNA viruses could be sensed by the host immune system. STING pathway activation also can occur with certain bacterial and parasitic infections, and more recently has been described to occur under conditions when mammalian DNA itself can attain access to the cytosol. Cytosolic DNA is detected upon binding to the sensor cyclic-GMP-AMP synthase (cGAS, MB21D1), which catalyzes the synthesis of cyclic GMP-AMP (cGAMP) from guanosine triphosphate (GTP) and adenosine triphosphate (ATP). cGAMP functions as a second messenger that binds and activates STING. Upon binding of cGAMP, STING undergoes conformational changes that trigger its trafficking from the ER to the Golgi to perinuclear endosomes. Consequently, STING recruits tank-binding kinase 1 (TBK1) and is, in turn, phosphorylated by TBK1, which renders it accessible for the binding of the transcription factor interferon regulatory factor 3 (IRF3). TBK1 then phosphorylates IRF3 which translocates to the nucleus to drive transcription of IFN-β and other genes.
References
1.Leticia Corrales,et al. Clin Cancer Res. 2015 Nov 1; 21(21): 4774–4779.
References
1.Leticia Corrales,et al. Clin Cancer Res. 2015 Nov 1; 21(21): 4774–4779.
Immunology/Inflammation
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STING
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STING agonist-30
产品货号 : M36613
cas no: 2951078-67-2
STING agonist-30 是一种有效的 STING 激动剂。STING agonist-30 表现出 STING 依赖性免疫激活。STING agonist-30 对多种病毒具有广泛的抑制作用,包括单纯疱疹病毒 (HSV)、轮状病毒和严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2)。 -
diABZI STING agonist-1
产品货号 : M36567
cas no: 2138299-33-7
diABZI STING agonist-1 是一个选择性的干扰素基因刺激受体 (STING) 的激动剂,其在人和小鼠中的 EC50 值分别为 130 nM 和 186 nM。 -
Dazostinag disodium
产品货号 : M36461
cas no: 2553413-93-5
Dazostinag disodium (TAK-676) 是一种干扰素基因刺激因子激动剂 (STING),触发 STING 信号通路激活和 I 型干扰素激活。Dazostinag disodium 也是一种免疫系统调节剂,具有完全消退和持久记忆的 T 细胞免疫功能。Dazostinag disodium 能够促进持久的干扰素依赖性抗肿瘤免疫反应。 -
diABZI-C2-NH2
产品货号 : M35133
cas no: 2137975-93-8
diABZI-C2-NH2是一种含有伯胺功能的活性类似物,是一种 STING 激动剂。 -
diABZI STING agonist-1 (Tautomerism)
产品货号 : M32885
cas no: 2138498-18-5
diABZI STING agonist-1 Tautomerism (compound 3) 是一个选择性的干扰素基因刺激受体 (STING) 的激动剂,其在人和小鼠中的 EC50 值分别为 130 nM 和 186 nM。。