ROS
ROS, produced by various biochemical and physiological oxidative processes in the body, are also associated with numerous physiological and pathophysiological processes. ROS play a major role in the pathogenesis of various human diseases. At low concentrations, ROS exhibit beneficial effects by regulating intracellular signaling and homeostasis; at high levels, however, ROS play a major role in the damage of proteins, lipids, and DNA. Antioxidant defense systems in the human body maintain the balance between the production and neutralization of ROS and include superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST), and glutathione (GSH). However, imbalances between ROS and antioxidant defense systems lead to oxidative stress, which initiates carcinogenesis. ROS have also been implicated in the mediation of apoptosis in cancer cells. The increased level of mitochondrial ROS was shown to promote cell proliferation, cell survival, cell migration, and epithelial-mesenchymal transition through mitogen-activated protein kinase (MAPK) and RasERK activation, ROS also elevated the p66Shc protein level, ErbB-2 level for cell proliferation.
References
1.Prasad S, et al. Cancer Lett. 2017;387:95–105.
References
1.Prasad S, et al. Cancer Lett. 2017;387:95–105.
Immunology/Inflammation
Amino Acids and Derivatives(42)
Antiviral(77)
CD110(2)
Cell wall(0)
Complement System(33)
FLAP(9)
Hydroxylase(14)
Interferon Receptor(6)
IRAK(24)
IκB kinase (IKK)(41)
Lipoxygenase(53)
LTR(13)
MyD88(6)
NOS(85)
PD-1/PD-L1(38)
PGE synthase(14)
RLR(4)
ROS(61)
Scavenger Receptor(2)
SphK(3)
STING(27)
TLR(68)
ROS
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Fagomine
产品货号 : M37948
cas no: 53185-12-9
Fagomine 是一种温和的糖苷酶 (glycosidase) 抑制剂,Fagomine 作用于 Amyloglucosidase (A.niger),β-Glucosidase (bovine) 和 Isomaltase (yeast),Ki 分别为 4.8 μM,39 μM 和 70 μM。 -
Moracin C
产品货号 : M37739
cas no: 69120-06-5
Moracin C,一种天然产物,是一种抗炎剂。Moracin C 抑制 LPS 激活的活性氧 (ROS) 和一氧化氮 (NO) 从细胞中释放。 -
Xanthine oxidase-IN-10
产品货号 : M37223
cas no: 851429-65-7
Xanthine oxidase-IN-10 (XO8 analog) 是黄嘌呤氧化酶 (XO) 抑制剂。 -
ROS inducer 1
产品货号 : M36961
cas no: 2921602-31-3
ROS inducer 1 (化合物 I29) 是一种杀菌剂,其对 Xanthomonas axonopodis pv. citri (Xac)、Xanthomonas oryzae pv. oryzae (Xoo) 以及 Pseudomonas syringae pv. actinidiae (Psa) 的 EC50 值分别为 5.73、6.62 以及 9.05 μg/mL。ROS inducer 1 能有效诱 Xanthomonas 细胞内 ROS 的产生,并抑制水稻白叶枯病。ROS inducer 1 具有研究农作物细菌感染的潜力。 -
(E/Z)-GSK5182
产品货号 : M36812
cas no: 2699724-40-6
(E/Z)-GSK5182 是 (E)-GSK5182 和 (Z)-GSK5182 的消旋体。GSK5182 是一种高效选择性,具有口服活性的 ERRγ 反向激动剂,其 IC50 值为 79 nM。GSK5182 还能增加肝癌细胞中 reactive oxyen species (ROS) 的产生。