NOS
Nitric oxide (NO) is an unorthodox messenger molecule, which has numerous molecular targets. NO controls servoregulatory functions such as neurotransmission or vascular tone (by stimulating NO-sensitive guanylyl cyclase), regulates gene transcription and mRNA translation (e.g. by binding to iron-responsive elements), and produces post-translational modifications of proteins (e.g. by ADP ribosylation). In mammals, NO can be generated by three different isoforms of the enzyme NO synthase (NOS; l-arginine, NADPH:oxygen oxidoreductases, NO forming; EC 1.14.13.39). The isozymes are referred to as neuronal ‘n’NOS (or NOS I), inducible ‘i’NOS (or NOS II), and endothelial ‘e’NOS (or NOS III). The known NOS enzymes are usually referred to as ‘dimeric’ in their active form, ignoring the required calmodulins (CaMs) which, strictly speaking, mean they are tetramers (of two NOS monomers associated with two CaMs). They contain relatively tightly-bound cofactors (6R)-5,6,7,8-tetrahydrobiopterin (BH% ), FAD, FMN and iron protoporphyrin IX (haem) and probably (although see below) catalyse a reaction of arginine, NADPH, and oxygen to the free radical NO, citrulline and NADP.
All isoforms of NOS utilize l-arginine as the substrate, and molecular oxygen and reduced nicotinamide-adenine-dinucleotide phosphate (NADPH) as co-substrates. All three NOS isozymes have regulatory functions in the cardiovascular system. Neuronal NOS is involved in central regulation of blood pressure, and nNOS-containing (nitrergic) nerves can dilate certain vascular beds. The most important isoform is eNOS, which keeps blood vessels dilated, controls blood pressure, and has numerous other vasoprotective and anti-atherosclerotic effects. iNOS is constantly active and not regulated by intracellular Ca2+ concentrations.
References
1.Alderton WK, et al. Biochem J. 2001;357(Pt 3):593–615.
2.F?rstermann U,et al. Eur Heart J. 2012;33(7):829–837d.
All isoforms of NOS utilize l-arginine as the substrate, and molecular oxygen and reduced nicotinamide-adenine-dinucleotide phosphate (NADPH) as co-substrates. All three NOS isozymes have regulatory functions in the cardiovascular system. Neuronal NOS is involved in central regulation of blood pressure, and nNOS-containing (nitrergic) nerves can dilate certain vascular beds. The most important isoform is eNOS, which keeps blood vessels dilated, controls blood pressure, and has numerous other vasoprotective and anti-atherosclerotic effects. iNOS is constantly active and not regulated by intracellular Ca2+ concentrations.
References
1.Alderton WK, et al. Biochem J. 2001;357(Pt 3):593–615.
2.F?rstermann U,et al. Eur Heart J. 2012;33(7):829–837d.
Immunology/Inflammation
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NOS
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Anhydronotoptol
产品货号 : M37804
cas no: 88206-51-3
Anhydronotoptol 是一种有效的 一氧化氮生成抑制剂。Anhydronotoptol 抑制 LPS 诱导的 RAW 264.7 细胞 NO 生成,其 IC50 值为 36.6 μM。 -
Hulupinic acid
产品货号 : M37772
cas no: 1891-42-5
Hulupinic acid 是啤酒花酸的主要氧化产物。 -
6-Methoxynaringenin
产品货号 : M37759
cas no: 94942-49-1
6-Methoxynaringenin 是一种天然黄酮类化合物,可抑制 NO 产生,IC50 为 25.8 μM。 -
iNOS-IN-14
产品货号 : M37327
cas no: 945762-00-5
iNOS-IN-14 (3-bromo-1H-indazole-7-carbonitrile) is a potent nitric oxide synthase (NOS) inhibitor that inhibits the NADPH oxidase activity of nNOS. -
MSU-42011
产品货号 : M36915
cas no: 2456434-36-7
MSU-42011 是一种具有口服活性的类视黄醇 X 受体 (RXR) 激动剂。MSU-42011 可以有效抑制 iNOS 以及 p-ERK 蛋白水平的表达。MSU-42011 具有免疫调节和抗肿瘤活性。MSU-42011 可用于癌症的研究。