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CMV
Human cytomegalovirus (HCMV) infects most individuals in the world, usually without producing overt symptoms. The broad cellular tropism of HCMV likely contributes to the diverse number of pathologies associated with infection.The deletion of glycoprotein B (gB) renders HCMV incapable of entering cells unless a chemical fusogen (ie polyethylene glycol) is added. HCMV gB has been shown to engage with a number of cellular receptors, including EGF-R, PDGF-Rα, tetherin and integrins (α2β1, α6β1 and αvβ3). Synthesis of a protein on a ribosome (RIB) is digested in the proteasome (PRO), transport of peptides into the endoplasmic reticulum (ER) by the transporter associated with antigenic peptides (TAP) and display, together with class I HLA molecules, at the plasma membrane. HCMV proteins pp65, UL97, US3, US6, US2 and US11 reduce display of mature class I complexes. HCMV proteins UL18 and UL40 present decoy signals to prevent immune attack. HCMV proteins UL16, UL141, UL142 plus micro-RNA UL112-1 block the display of stress ligands, which would otherwise precipitate immune attack.
References
1.Griffiths P,et al. J Pathol. 2015 Jan;235(2):288-97.
References
1.Griffiths P,et al. J Pathol. 2015 Jan;235(2):288-97.
Microbiology/Virology
CMV
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CEF20
产品货号 : M30386
cas no: 153045-21-7
CEF20, a CEF control peptide pool, is an HLA-A*0201-restricted epitope from cytomegalovirus pp65 (495-503).
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Brincidofovir
产品货号 : M14523
cas no: 444805-28-1
Brincidofovir（CMX 001；Cidofovir HDP）是无环核苷酸磷酸酯的脂质缀合物。
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CFI02
产品货号 : M13838
cas no: 273735-28-7
CFI02 (CFI-02) 是人巨细胞病毒 (HCMV) 糖蛋白 B 介导的融合的特异性抑制剂，针对实验室适应的 HCMV 毒株 AD169，IC50 为 40 nM。
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Tomeglovir
产品货号 : M13667
cas no: 233254-24-5
Tomeglovir (BAY 384766) 是一种有效的、高选择性的、非核苷类巨细胞病毒 (CMV) 复制抑制剂。
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GW 275175X
产品货号 : M13479
cas no: 217950-62-4
GW 275175X 是 BDCRB 的衍生物，通过抑制病毒 DNA 成熟而表现出抗 HCMV 活性。
