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HCV
Hepatitis C virus(HCV) is an enveloped, single-stranded RNA virus, belonging to the Flaviviridae family. HCV infection is a major cause of chronic hepatitis worldwide, leading to steatosis, liver cirrhosis and hepatocellular carcinoma. Significant advances in understanding the mechanism of HCV infection have been made since the development of a cell system reproducing the complete HCV cell cycle in vitro. HCV represents a new paradigm in interactions between the virus and its target cell, the human hepatocyte, due to the centralrole of lipoproteins in the HCV life cycle. HCV cell entry is a multi-step process: heparan sulphate and/or low-density lipoprotein receptor are cell surface factors mediating an initial virus attachment; subsequent virus interaction with tetraspanin CD81 and the human scavenger receptor SR-BI, the main HCV receptors, tiggers virus movement to the tight junctions and its uptake via Claudin-1 and occluding.
References
1.Budkowska A. Pol J Microbiol. 2009;58(2):93–98.
References
1.Budkowska A. Pol J Microbiol. 2009;58(2):93–98.
Microbiology/Virology
HCV
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HCV-IN-4
产品货号 : M30167
cas no: 2058080-25-2
HCV-IN-4 is a potent and orally active HCV NS5A inhibitor, shows great potency against GT1a, GT2b, GT3a, GT1a Y93H and GT1a L31V, with EC90s of 3 pM, 0.3 nM, 0.01 nM, 0.5 nM and 0.02 nM, respectively.
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Chlorcyclizine
产品货号 : M28856
cas no: 82-93-9
CHLORCYCLIZINE 是一种组胺 H1 拮抗剂和一种有效的丙型肝炎病毒 (HCV) 进入抑制剂。
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SB-734117
产品货号 : M28776
cas no: 607368-97-8
SB-734117 抑制多种 HCMV 病毒株的高效复制。 SB-734117 表现出多种药理学，是 AGC 和 CMCG 激酶组中多种蛋白质的抑制剂。
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HCV-IN-31
产品货号 : M28773
cas no: 1998705-62-6
HCV-IN-31 是一种 HCV 抑制剂，EC50/EC95 为 15.7 μM。
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Samatasvir
产品货号 : M28765
cas no: 1312547-19-5
Samatasvir 是 HCV 非结构蛋白 5A 的泛基因型抑制剂。
