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HIV
The HIV epidemic continues to spread and affect communities throughout the world. Ninety percent of people living with HIV live in developing countries, over two-thirds of the total number living in sub-Saharan Africa. Four out of five HIV positive women and 87% of HIV positive children in the world live in Africa. Prevalence of HIV, on the other hand, has continued to increase due to these reductions in death rates and the resultant extension in the lifespan of people living with HIV/AIDS. HIV is not dormant during the so called clinically latent period. Studies of lymph node biopsy specimens from HIV-infected individuals using nucleic acid hybridization techniques have demonstrated active viral replication at all stages of disease. These genetic variants may also enable the virus to escape immune surveillance activity. This active replication of HIV is accompanied by a rapid turnover of CD4 lymphocyte cells.
References
1.Zelalem Temesgen, et al. Ann Allergy Asthma Immunol 1999;83:1–7.
References
1.Zelalem Temesgen, et al. Ann Allergy Asthma Immunol 1999;83:1–7.
Microbiology/Virology
HIV
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Kaempferol 3-O-(6-galloyl)-beta-D-glucopyranoside
产品货号 : M37787
cas no: 56317-05-6
Kaempferol-3-O-(6′′-galloyl)-β-glucopyranoside 是一种吡喃葡萄糖苷。Kaempferol-3-O-(6′′-galloyl)-β-glucopyranoside 抑制 HIV-2 RNase H 的 IC50 为 5.19 μM。
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TERT-IN-1
产品货号 : M37513
cas no: 257891-65-9
TERT-IN-1 has anti-HIV activity and can be used to study HIV infection.
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2-Amino-6-bromopyridine
产品货号 : M36860
cas no: 19798-81-3
2-Amino-6-bromopyridine has inhibitory effect on HIV-68 protease.
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Ibalizumab
产品货号 : M36665
cas no: 680188-33-4
Ibalizumab (TMB-355) 是一种人源化 IgG4 单克隆抗体，通过与 CD4 受体结合来阻止 HIV 细胞进入。Ibalizumab 具有用于 HIV-1 感染研究的潜力。
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Atevirdine
产品货号 : M36355
cas no: 136816-75-6
Atevirdine 是一种有效的非核苷 HIV-1 逆转录酶抑制剂。Atevirdine 抑制导致病毒增殖的非核苷逆转录酶。
