Tomeglovir ( BAY 38-4766 | BAY 384766 )

产品货号. M13667 CAS No. 233254-24-5

Tomeglovir (BAY 384766) 是一种有效的、高选择性的、非核苷类巨细胞病毒 (CMV) 复制抑制剂。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
100MG	获取报价	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

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生物学信息

产品名称

Tomeglovir
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Tomeglovir (BAY 384766) 是一种有效的、高选择性的、非核苷类巨细胞病毒 (CMV) 复制抑制剂。
产品描述

Tomeglovir (BAY 384766) is a potent, highly selective, nonnucleoside inhibitor of cytomegalovirus (CMV) replication; selectively inhibits not only HCMV strains, including ganciclovir-resistant clinical isolates, but also a number of monkey and rodent cytomegaloviruses.CMV Infection Phase 2 Discontinued.
体外实验

Tomeglovir (BAY 38-4766) is a potent anti-CMV agent, with IC50s of 0.34 μM and 0.039 μM for HCMV and MCMV. Tomeglovir also suppresses HELF and NIH 3T3 cells, with CC50s of 85 μM and 62.5 μM, respectively. Tomeglovir (BAY 38-4766) inhibits HCMV Davis and various monkey CMV strains with EC50s of 1.03 ± 0.57 μM and < 1 μM.
体内实验

Tomeglovir (BAY 38-4766; 3, 10, 30, 100 mg/kg, p.o.) dose-dependently reduces MCMV-DNA in salivary glands, livers and kidneys of MCMV-infected NOD-SCID mice, and prolongs the survival of the mice. Tomeglovir (10, 25 and 50 mg/kg) shows antiviral activity in the hollow fiber mouse model. Tomeglovir (BAY 38-4766) shows antiviral activity in SCID mice with MCMV, and the LD50 is >2000 mg/kg in mice and rats.
同义词

BAY 38-4766 | BAY 384766
通路

Microbiology/Virology
靶点

CMV
受体

CMV
研究领域

Infection
适应症

CMV Infection

化学信息

CAS Number

233254-24-5
分子量

441.546
分子式

C23H27N3O4S
纯度

>98% (HPLC)
溶解度

DMSO : ≥ 108 mg/mL 244.60 mM
SMILES

O=C(NC1=CC=C(NS(=O)(C2=C3C=CC=C(N(C)C)C3=CC=C2)=O)C=C1)C(C)(C)CO
化学全称

N-(4-(((5-(Dimethylamino)-1-naphthyl)sulfonyl)amino)phenyl)-3-hydroxy-2,2-dimethylpropionamide

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Weber O, et al. Antiviral Res. 2001 Mar;49(3):179-89. 2. Buerger I, et al. J Virol. 2001 Oct;75(19):9077-86. 3. Reefschlaeger J, et al. J Antimicrob Chemother. 2001 Dec;48(6):757-67.

计算器

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摩尔计算器

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