
Tomeglovir
CAS No. 233254-24-5
Tomeglovir ( BAY 38-4766 | BAY 384766 )
产品货号. M13667 CAS No. 233254-24-5
Tomeglovir (BAY 384766) 是一种有效的、高选择性的、非核苷类巨细胞病毒 (CMV) 复制抑制剂。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
100MG | 获取报价 | 有现货 |
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200MG | 获取报价 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Tomeglovir
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Tomeglovir (BAY 384766) 是一种有效的、高选择性的、非核苷类巨细胞病毒 (CMV) 复制抑制剂。
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产品描述Tomeglovir (BAY 384766) is a potent, highly selective, nonnucleoside inhibitor of cytomegalovirus (CMV) replication; selectively inhibits not only HCMV strains, including ganciclovir-resistant clinical isolates, but also a number of monkey and rodent cytomegaloviruses.CMV Infection Phase 2 Discontinued.
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体外实验Tomeglovir (BAY 38-4766) is a potent anti-CMV agent, with IC50s of 0.34 μM and 0.039 μM for HCMV and MCMV. Tomeglovir also suppresses HELF and NIH 3T3 cells, with CC50s of 85 μM and 62.5 μM, respectively. Tomeglovir (BAY 38-4766) inhibits HCMV Davis and various monkey CMV strains with EC50s of 1.03 ± 0.57 μM and < 1 μM.
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体内实验Tomeglovir (BAY 38-4766; 3, 10, 30, 100 mg/kg, p.o.) dose-dependently reduces MCMV-DNA in salivary glands, livers and kidneys of MCMV-infected NOD-SCID mice, and prolongs the survival of the mice. Tomeglovir (10, 25 and 50 mg/kg) shows antiviral activity in the hollow fiber mouse model. Tomeglovir (BAY 38-4766) shows antiviral activity in SCID mice with MCMV, and the LD50 is >2000 mg/kg in mice and rats.
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同义词BAY 38-4766 | BAY 384766
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通路Microbiology/Virology
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靶点CMV
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受体CMV
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研究领域Infection
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适应症CMV Infection
化学信息
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CAS Number233254-24-5
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分子量441.546
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分子式C23H27N3O4S
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纯度>98% (HPLC)
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溶解度DMSO : ≥ 108 mg/mL 244.60 mM
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SMILESO=C(NC1=CC=C(NS(=O)(C2=C3C=CC=C(N(C)C)C3=CC=C2)=O)C=C1)C(C)(C)CO
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化学全称N-(4-(((5-(Dimethylamino)-1-naphthyl)sulfonyl)amino)phenyl)-3-hydroxy-2,2-dimethylpropionamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Weber O, et al. Antiviral Res. 2001 Mar;49(3):179-89.
2. Buerger I, et al. J Virol. 2001 Oct;75(19):9077-86.
3. Reefschlaeger J, et al. J Antimicrob Chemother. 2001 Dec;48(6):757-67.
产品手册




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