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Cidofovir

CAS No. 113852-37-2

Cidofovir ( GS-0504 | HPMPC | (S)-HPMPC )

产品货号. M10487 CAS No. 113852-37-2

西多福韦二磷酸酯的前药,通过选择性抑制病毒 DNA 聚合酶来抑制巨细胞病毒 (CMV) 病毒复制。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥251 有现货
10MG ¥389 有现货
50MG ¥656 有现货
100MG ¥1029 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Cidofovir
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    西多福韦二磷酸酯的前药,通过选择性抑制病毒 DNA 聚合酶来抑制巨细胞病毒 (CMV) 病毒复制。
  • 产品描述
    The prodrug of cidofovir diphosphate that inhibits cytomegalovirus (CMV) viral replication by selectively inhibiting viral DNA polymerases; also incorporates itself into viral DNA hence inhibiting viral DNA synthesis during reproduction.CMV Infection Approved(In Vitro):Cidofovir (5-100 μM, 72 hours) has antiviral activity against feline herpesvirus type-1 (FHV-1) with an IC50 of 11 μM, and can reduce Crandell-Reese feline kidney cell counts in a dose-dependent manner.Cidofovir (10-1000 μM, 24-120 hours) can reduce cancer cell viability and induces apoptosis.(In Vivo):Cidofovir (subcutaneous injection, 100 mg/kg, 3-6 days interval, 21 days) is highly protective against death from cowpox virus (CPV) infection at high doses in female weanling BALB/c mice.
  • 体外实验
    Cidofovir (5-100 μM, 72 hours) has antiviral activity against feline herpesvirus type-1 (FHV-1) with an IC50 of 11 μM, and can reduce Crandell-Reese feline kidney cell counts in a dose-dependent manner.Cidofovir (10-1000 μM, 24-120 hours) can reduce cancer cell viability and induces apoptosis. Cell Cytotoxicity AssayCell Line:Crandell-Reese feline kidney(CRFK) cellsConcentration:10-100 μMIncubation Time:72 hoursResult:Reduced CRFK cells by 9.1%.Cell Viability Assay Cell Line:Caco-2, FTC-133, HeLa, Hep-G2, MDA-MB-231, NCI-H1975 and PC-3 cells Concentration:10-1000 μM Incubation Time:24, 48, 72, 96, 120 hoursResult:Resulted in a gradual decrease in tumor cell viability with time and concentration increasing and inhibited the number of FTC-133 cell clones by about 55% at 100 μM comparing to the untreated group.Apoptosis Analysis Cell Line:FTC-133 cells Concentration:100 μM Incubation Time:96 hours Result:Showed a significant increase in the expression of pro-apoptotic proteins, such as cytochrome c, phospho-p53 (S15) and caspase-3 by 130%, 49%, and 46%, respectively while the anti-apoptotic protein Bcl-x decreased significantly by 57% comparing to the untreated cells.
  • 体内实验
    Cidofovir (subcutaneous injection, 100 mg/kg, 3-6 days interval, 21 days) is highly protective against death from cowpox virus (CPV) infection at high doses in female weanling BALB/c mice. Animal Model:Female weanling BALB/c mice infected with cowpox virus (CPV)Dosage:100 mg/kgAdministration:Subcutaneous injection; 3-6 days interval; 21 days Result:Prevented 80-100% of mouse deaths when administered on the first 4-3 days before infection.Protected 35-50% of mice when administered on the fourth day after infection, and 10-20% when administered on the sixth day.
  • 同义词
    GS-0504 | HPMPC | (S)-HPMPC
  • 通路
    Microbiology/Virology
  • 靶点
    CMV
  • 受体
    DNA/RNASynthesis
  • 研究领域
    Infection
  • 适应症
    CMV Infection

化学信息

  • CAS Number
    113852-37-2
  • 分子量
    279.187
  • 分子式
    C8H14N3O6P
  • 纯度
    >98% (HPLC)
  • 溶解度
    H2O: 6.4 mg/mL (Need warming)
  • SMILES
    OC[C@@H](OCP(O)(O)=O)CN1C=CC(N)=NC1=O
  • 化学全称
    Phosphonic acid, P-[[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

产品手册
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