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Kinesin
Kinesin is eukaryotic-conserved motor proteins that move along MTs with ATP hydrolysis. Each kinesin has a motor domain, which converts the energy ATP hydrolysis into mechanical work and which defines a protein as a kinesin.Kinesin plays an essential role in vesicle and organelle transport. It transfers vesicles to the presynaptic axonal regions in order for the mediation of synaptic transmission to occur.The importance of kinesin is underscored by the serious medical consequences, such as diseases like Parkinson’s, Alzheimer’s and Huntington’s, which appear to implicate kinesin’s interactions with disease-associated proteins.
References
1.Takahiro Hamada, in International Review of Cell and Molecular Biology, 2014
References
1.Takahiro Hamada, in International Review of Cell and Molecular Biology, 2014
Cytoskeleton/Cell Adhesion Molecules
Kinesin
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UMK57
产品货号 : M34457
cas no: 342595-74-8
UMK57 是一种专门促进 k-MT 附着错误纠正以抑制染色体错误分离的小分子化合物，可以通过破坏有丝分裂过程中动粒微管 (k-MT) 附着的稳定性，从而提高染色体分离保真度。
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Kif15-IN-2
产品货号 : M32983
cas no: 672926-33-9
Kif15-IN-2 是一种驱动蛋白 Kif15 的抑制剂，主要用于细胞增殖性疾病的研究。
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Paprotrain
产品货号 : M26357
cas no: 57046-73-8
Paprotrain 抑制 MKLP-2 的 ATPase 活性，IC50 为 1.35 μM，Ki 为 3.36 μM。
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Eg5 Inhibitor V, trans-24
产品货号 : M26190
cas no: 869304-55-2
Eg5 Inhibitor V, trans-24 是一种特异性、有效的 Eg5 激动剂抑制剂，可用于癌症研究，IC50 值为 0.65 uM。
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Mps1-IN-3
产品货号 : M23708
cas no: 1609584-72-6
Mps1-IN-3 是一种有效的选择性 MPS1 激酶抑制剂 (IC50: 50 nM)。
