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Dynein
Cytoplasmic dynein-1 (hereafter, dynein) is a large protein complex that drives long-range retrograde transport along microtubules.It carries a broad range of cargos, from mRNAs to entire organelles and plays a key role in cellular processes as diverse as fast axonal transport, Golgi dynamics and mitosis. Structurally, dynein consists of a motor domain that produces mechanical motion and a tail domain that is important for cargo binding, regulation and homodimerisation. Dynein works together with another large protein complex called dynactin which is required for virtually all known dynein functions.
References
1.Carter AP,et al. Curr Opin Struct Biol. 2016 Apr;37:62-70.
References
1.Carter AP,et al. Curr Opin Struct Biol. 2016 Apr;37:62-70.
Cytoskeleton/Cell Adhesion Molecules
Dynein
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Dynarrestin
产品货号 : M13550
cas no: 2222768-84-3
Dynarrestin 是一种新型细胞质动力蛋白 1 和 2 抑制剂，在体外可逆地抑制细胞质动力蛋白 1 依赖性微管结合和运动，而不影响 ATP 水解。
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Dynein2-IN-37
产品货号 : M12813
cas no: 1823133-56-7
Dynein2-IN-37 (Ciliobrevin Analog 37) 是一种有效的、选择性的细胞质动力蛋白 2 ATPase 活性拮抗剂，IC50 为 11 uM。
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Ciliobrevin D
产品货号 : M11528
cas no: 1370554-01-0
Ciliobrevin D 是一种细胞渗透性、可逆性、特异性的细胞质动力蛋白抑制剂。
