Dynamin
Dynamin was originally identified as a GTPase that co-purified with brain microtubules. Mammalian genomes contain three dynamin genes16. The proteins encoded by these genes share the same domain organization and 80% overall homology, but they have distinct expression patterns. Dynamin is localized at sites of endocytosis. It is also found at actin meshworks nucleated by the actin-related protein 2/3 (ARP2/3) complex, such as membrane ruffles, podosomes and invadopodia, and at actin pedestals induced by pathogenic bacteria (such as enteropathogenic Escherichia coli (EPEC)). Other dynamin-like proteins (DLPs), including atlastin, dynamin-related protein 1 (DRP1), optic atrophy 1 homologue (OPA1) and mitofusin, localize to sites of intracellular membrane fission and fusion in the endoplasmic reticulum (ER), mitochondria and peroxisomes.
References
1.Ferguson SM,et al. Nat Rev Mol Cell Biol. 2012 Jan 11;13(2):75-88.
References
1.Ferguson SM,et al. Nat Rev Mol Cell Biol. 2012 Jan 11;13(2):75-88.
Cytoskeleton/Cell Adhesion Molecules
Dynamin
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Dynamin IN-2
产品货号 : M35809
cas no: 1345853-49-7
Dynamin IN-2 (compound 43),一种Wiskostatin (HY-12534) 类似物,是一种有效的 dynamin 抑制剂,对 dynamin I GTPase 的 IC50 为 1.0 μM。Dynamin IN-2 还可阻断网格蛋白介导的内吞作用 (CME),IC50 为 9.5 μM。 -
Dynapyrazole A
产品货号 : M34768
cas no: 2226517-75-3
Dynapyrazole A 是一种特异性的微管动力蛋白抑制剂,可特异性抑制微管刺激的动力蛋白的 ATP 酶活性,但不会阻断微管独立的基础活性。 -
Dynamin inhibitory peptide, myristoylated TFA
产品货号 : M30697
cas no: 251634-22-7
Cell-permeable version of dynamin inhibitory peptide, an inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis. Reduces NMDA receptor internalization. -
Tetradecyltrimethylammonium bromide
产品货号 : M27656
cas no: 1119-97-7
MitMAB 是一种 Dynamin GTPase 活性抑制剂,也是一种具有不对称结构的阳离子表面活性剂。 -
Trimethyloctadecylammonium bromide
产品货号 : M22957
cas no: 1120-02-1
Trimethyloctadecylammium bromide 是 Dynamin I 的抑制剂 (IC50 : 1.9 μM),也抑制 Dynamin II。