Microtubule/Tubulin
Microtubules are major dynamic structural components in cells. They are important in the development and maintenance of cell shape, in cell reproduction and division, in cell signaling, and in cellular movement. Microtubules are the target of a diverse group of anticancer drugs, most of which are derived from natural products. Microtubules are highly dynamic polymers of heterodimers of a and b tubulin, arranged parallel to a cylindrical axis to form tubes of 25 nm diameter that may be many mm long. Polymerization of microtubules occurs by a nucleation-elongation mechanism in which the formation of a short microtubule ‘nucleus‘ is followed by elongation of the microtubule at its ends by the reversible, noncovalent addition of tubulin dimers. Microtubules are not simple equilibrium polymers. They exhibit complex polymerization dynamics that use energy provided by the hydrolysis of GTP, and these dynamics are crucial to their cellular functions. A large number of chemically diverse substances bind to tubulin or microtubules and inhibit cell proliferation by acting on microtubules. Many of these have become drugs that are highly useful in the treatment of various forms of cancer or are currently in clinical trials. Microtubules are the target of a diverse group of anticancer drugs, most of which are derived from natural products.
References
1.Jordan MA. Curr Med Chem Anticancer Agents. 2002;2(1):1–17.
References
1.Jordan MA. Curr Med Chem Anticancer Agents. 2002;2(1):1–17.
Cytoskeleton/Cell Adhesion Molecules
Microtubule/Tubulin
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Dolastatin 10
产品货号 : M29578
cas no: 110417-88-4
Dolastatin 10 是一种有效的抗有丝分裂肽,可抑制微管蛋白聚合。 -
Tubulin inhibitor 24
产品货号 : M28918
cas no: 2415761-65-6
微管蛋白抑制剂 24 是一种有效的抑制剂,可以抑制微管蛋白聚合。 -
LP-261
产品货号 : M28789
cas no: 915412-67-8
LP-261 是一种新型微管蛋白靶向抗癌剂,可与微管蛋白上的秋水仙碱位点结合,诱导 G2/M 期阻滞。 -
MAP4343
产品货号 : M28721
cas no: 511-26-2
Map4343 是孕烯醇酮的 3-甲基醚衍生物。 Map4343 在体外与微管相关蛋白 2 (MAP2) 结合并刺激微管蛋白聚合,从而增强神经突延伸并保护神经元免受神经毒剂的侵害。 -
TTBK1-IN-2
产品货号 : M28535
cas no: 2765453-51-6
TTBK1-IN-2 是一种 Tau-微管蛋白激酶 (TTBK1) 抑制剂,IC50 分别为 0.24 和 4.22 μM。 TTBK1-IN-2 降低细胞培养物和转基因 TDP-43 小鼠脊髓中的 TDP-43 磷酸化。