MAP4343

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Map4343 是孕烯醇酮的 3-甲基醚衍生物。 Map4343 在体外与微管相关蛋白 2 (MAP2) 结合并刺激微管蛋白聚合，从而增强神经突延伸并保护神经元免受神经毒剂的侵害。

Map4343 is a 3-methyl ether derivative of pregnenolone. Map4343 binds to microtubule associated protein 2 (MAP2) in vitro and stimulates tubulin polymerization, resulting in enhanced neurite extension and protection of neurons from neurotoxic agents.

MAP4343 (40 μM; 15 or 30 min) stimulates microtubule polymerization in vitro.MAP4343 (30 μM; 2-8 d) stimulates nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells.MAP4343 (20 μM; 1 h) protects against microtubule depolymerization induced by Nocodazole in PC12 cells .

MAP4343 (12 mg/kg; daily s.c. for 28 d) improves the recovery of locomotor function after spinal cord injury (SCI) in rats.MAP4343 (4 mg/kg; daily s.c. for 6 d) increases MAP2 levels in spinal cord after SCI in rats.MAP4343 (4 mg/kg; daily s.c. for 6 d) increases the size of lumbar spinal motoneurons' dendrite arbours after SCI in rats. Animal Model:Adult Sprague-Dawley male rats with spinal cord injuryDosage:12 mg/kg Administration:Daily s.c. for 28 days Result:Increased the number of animals able to walk with weight-supported plantar steps.Showed forelimb-hindlimb coordination at the end of the study.

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Cytoskeleton/Cell Adhesion Molecules

Microtubule/Tubulin

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511-26-2

660

C44H67O4

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (75.64 mM)

C[C@](CC1)([C@@H](CC2)[C@H]3[C@H]1[C@@](C)(CC[C@@H](C1)OC)C1=CC3)[C@H]2C(C)=OC[C@](CC1)([C@@H](CC2)[C@H]3[C@H]1[C@@](C)(CC[C@@H](C1)OC)C1=CC3)[C@H]2C(C)=O

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(-20℃)

With Ice Pack

≥ 2 years