SR31527

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SR31527 is a novel allosteric Kinesin-like protein KIFC1 inhibitor that inhibits microtubule-stimulated KIFC1 ATPase activity with IC50 of 6.6 uM.

SR31527 is a novel allosteric Kinesin-like protein KIFC1 inhibitor that inhibits microtubule-stimulated KIFC1 ATPase activity with IC50 of 6.6 uM, binds directly to KIFC1 with Kd of 25.4 nM; prevents bipolar clustering of extra centrosomes in TNBC cells and significantly reducesTNBC cell colony formation and viability (MDA-MB-231, BT549 and MDA-MB-435s cells IC50=20-30 uM), with less toxicity to normal fibroblasts.

SR 31527;SR-31527

Cytoskeleton/Cell Adhesion Molecules

Kinesin

Kinesin

——

——

311814-78-5

319.81

C15H14ClN3OS

>98% (HPLC)

——

COC1=CC=C(C2=[N+](C3=CC=CC=C3)SC(N)=N2)C=C1.[Cl-]

5-amino-3-(4-methoxyphenyl)-2-phenyl-1,2,4-thiadiazol-2-ium chloride

(-20℃)

With Ice Pack

≥ 2 years