Merestinib ( LY2801653 )

产品货号. M17192 CAS No. 1206799-15-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Merestinib
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

LY2801653 is an orally available, small molecule inhibitor of the proto-oncogene c-Met (Ki: 2 nM) with potential antineoplastic activity.
产品描述

LY2801653 is an orally available, small molecule inhibitor of the proto-oncogene c-Met (Ki: 2 nM) with potential antineoplastic activity. LY2801653 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing the constitutively activated c-Met protein.
同义词

LY2801653
通路

Cytoskeleton/Cell Adhesion Molecules
靶点

Kinesin
受体

Met
研究领域

Cancer
适应症

——

CAS Number

1206799-15-6
分子量

552.54
分子式

C30H22F2N6O3
纯度

95%
溶解度

DMSO : ≥ 32 mg/mL. 57.92 mM
SMILES

c1(=O)c(ccc(n1c1ccc(cc1)F)C)C(=O)Nc1cc(c(cc1)Oc1cc2cnn(c2cc1c1cn[nH]c1)C)F
化学全称

——

1.Yan SB, Peek VL, Ajamie R, et al. Invest New Drugs. 2012 Dec 29. [Epub ahead of print]

计算器

产品手册

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