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TUG-891
CAS No. 1374516-07-0
TUG-891 ( TUG-891 | TUG 891 | TUG891 )
产品货号. M17264 CAS No. 1374516-07-0
TUG-891 是一种在肠道、脂肪细胞和促炎巨噬细胞中表达的 G 蛋白偶联受体 (GPCR)，可被长链游离脂肪酸激活。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥381 | 有现货 |
|
| 5MG | ￥624 | 有现货 |
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| 10MG | ￥948 | 有现货 |
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| 25MG | ￥1920 | 有现货 |
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| 50MG | ￥3216 | 有现货 |
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| 100MG | ￥4714 | 有现货 |
|
| 500MG | ￥9963 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称TUG-891
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述TUG-891 是一种在肠道、脂肪细胞和促炎巨噬细胞中表达的 G 蛋白偶联受体 (GPCR)，可被长链游离脂肪酸激活。
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产品描述TUG-891 is a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), which demonstrates both potential opportunity and possible challenges to therapeutic agonism. Activation of human FFA4 by TUG-891 also resulted in rapid phosphorylation and internalization of the receptor. TUG-891 was also a potent agonist of mouse FFA4, but it showed only limited selectivity over mouse FFA1, complicating its use in vivo in this species.
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体外实验TUG-891 displays similar signaling properties to the LCFA α-linolenic acid at human FFA4, including stimulation of Ca2+ mobilization, β-arrestin-1 and β-arrestin-2 recruitment, and extracellular signal-regulated kinase phosphorylation. Activation of human FFA4 by TUG-891 also results in rapid phosphorylation and internalization of the receptor.
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体内实验——
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同义词TUG-891 | TUG 891 | TUG891
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通路Cytoskeleton/Cell Adhesion Molecules
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靶点Kinesin
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受体GPR120
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研究领域Metabolic Disease
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适应症——
化学信息
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CAS Number1374516-07-0
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分子量364.41
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分子式C23H21FO3
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纯度>98% (HPLC)
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溶解度DMSO : ≥ 180 mg/mL 493.95 mM
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SMILESc1(c(ccc(c1)F)c1ccc(cc1)C)COc1ccc(cc1)CCC(=O)O
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化学全称3-(4-((4-fluoro-4'-methyl-[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoic acid
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Hopkins MM, Zhang Z, Liu Z, Meier KE. J Clin Med. 2016 Jan 26;5(2).
