KSP-IA ( KSP-IA; KSP IA; KSPIA )

产品货号. M15425 CAS No. 639074-49-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

KSP-IA
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A potent, specific, allosteric and cell-active inhibitor of KSP with IC50 of 11 nM; has no ihibitory activity toward other kinesins.
产品描述

A potent, specific, allosteric and cell-active inhibitor of KSP with IC50 of 11 nM; has no ihibitory activity toward other kinesins, includin CENP-E, MKLP-1, KIF-3A, and uKHC (IC50>50 uM); induces the formation of monoastral spindles, causes mitotic arrest in a dose-dependent manner (EC50=30 nM) in A2780 ovarian carcinoma cells; sustained KSP inhibition activates the proapoptotic protein, Bax, and both activation of the spindle checkpoint and subsequent mitotic slippage are required for Bax activation.
同义词

KSP-IA; KSP IA; KSPIA
通路

Cytoskeleton/Cell Adhesion Molecules
靶点

Kinesin
受体

Kinesin
研究领域

——
适应症

——

CAS Number

639074-49-0
分子量

356.42
分子式

C21H22F2N2O
纯度

>98% (HPLC)
溶解度

——
SMILES

CC(C)[C@H](N)C(N1[C@H](C2=CC=CC=C2)C=C(C3=CC(F)=CC=C3F)C1)=O
化学全称

(S)-2-amino-1-((S)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrol-1-yl)-3-methylbutan-1-one

1. Tao W, et al. Cancer Cell. 2005 Jul;8(1):49-59.

计算器

产品手册

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