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MK-0731
CAS No. 845256-65-7
MK-0731 ( MK0731 )
产品货号. M16139 CAS No. 845256-65-7
MK-0731 is a potent, selective kinesin spindle protein (KSP) inhibitor with IC50 of 2.2 nM, cell EC50 of 5.3 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥13527 | 有现货 |
|
| 50MG | ￥27378 | 有现货 |
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| 100MG | ￥37260 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称MK-0731
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述MK-0731 is a potent, selective kinesin spindle protein (KSP) inhibitor with IC50 of 2.2 nM, cell EC50 of 5.3 nM.
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产品描述MK-0731 is a potent, selective kinesin spindle protein (KSP) inhibitor with IC50 of 2.2 nM, cell EC50 of 5.3 nM; dispalys >20,000-fold selectivity for KSP over a panel of eight related kinesins (CENP-E, MKLP-1, Kif3A, Kif1B, uKHC, nKHC, KIF14, and MCAK); induces a mitotic block with an IC50 of 19 nM in cells that are refractory to paclitaxel due to P-gp overexpression; induces dose-dependent mitotic arrest in tumors and inhibits tumor growth in mouse xenograft.Solid Tumors Discontinued
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同义词MK0731
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通路Cytoskeleton/Cell Adhesion Molecules
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靶点Kinesin
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受体Kinesin
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研究领域Cancer
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适应症Solid Tumors
化学信息
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CAS Number845256-65-7
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分子量459.51
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分子式C25H28F3N3O2
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(N1[C@@](C2=CC=CC=C2)(CO)C=C(C3=CC(F)=CC=C3F)C1)N([C@@H]4[C@H](F)CN(C)CC4)C
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化学全称(S)-4-(2,5-difluorophenyl)-N-((3R,4S)-3-fluoro-1-methylpiperidin-4-yl)-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Cox CD, et al. J Med Chem. 2008 Jul 24;51(14):4239-52.
2. Cox CD, et al. Anticancer Agents Med Chem. 2010 Nov 1;10(9):697-712.
3. Holen K, et al. Invest New Drugs. 2012 Jun;30(3):1088-95.
2. Cox CD, et al. Anticancer Agents Med Chem. 2010 Nov 1;10(9):697-712.
3. Holen K, et al. Invest New Drugs. 2012 Jun;30(3):1088-95.
产品手册
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