Kinesore ( Kinesore )

产品货号. M14249 CAS No. 363571-83-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Kinesore
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Kinesore is a small molecule activator of kinesin-1 that inhibits KLC2-SKIP interaction with IC50 of 101 uM, Ki of 49 uM.
产品描述

Kinesore is a small molecule activator of kinesin-1 that inhibits KLC2-SKIP interaction with IC50 of 101 uM, Ki of 49 uM; inhibits kinesin-1 interactions with short linear peptide motifs found in organelle-specific cargo adaptors, yet activates kinesin-1's function of controlling microtubule dynamics in cells; induces the remodeling of the microtubule network.
同义词

Kinesore
通路

Cytoskeleton/Cell Adhesion Molecules
靶点

Kinesin
受体

Kinesin
研究领域

——
适应症

——

CAS Number

363571-83-9
分子量

536.18
分子式

C20H16Br2N4O4
纯度

>98% (HPLC)
溶解度

DMSO : 125 mg/mL 233.14 mM
SMILES

O=C(N/N=C/C1=C(C)N(C2=CC=CC([N+]([O-])=O)=C2)C(C)=C1)C3=CC(Br)=C(O)C(Br)=C3
化学全称

(E)-3,5-Dibromo-N'-((2,5-dimethyl-1-(3-nitrophenyl)-1H-pyrrol-3-yl)methylene)-4-hydroxybenzohydrazide

1. Randall TS, et al. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13738-13743.

计算器

产品手册

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