AZ82 ( KIFC1 inhibitor AZ82 )

产品货号. M11933 CAS No. 1449578-65-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

AZ82
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

AZ82 (KIFC1 inhibitor AZ82) is the first reported small molecule inhibitor.
产品描述

AZ82 (KIFC1 inhibitor AZ82) is the first reported small molecule inhibitor of motor protein KIFC1 that inhibits the MT-stimulated KIFC1 enzymatic activity in an ATP-competitive and MT-noncompetitive manner with Ki of 43 nM; effectively engages with the minus end-directed KIFC1 motor inside cells to reverse the monopolar spindle phenotype induced by the inhibition of the plus end-directed kinesin Eg5; causes centrosome declustering in BT-549 breast cancer cells with amplified centrosomes.
同义词

KIFC1 inhibitor AZ82
通路

Cytoskeleton/Cell Adhesion Molecules
靶点

Kinesin
受体

Kinesin
研究领域

——
适应症

——

CAS Number

1449578-65-7
分子量

560.60
分子式

C28H31F3N4O3S
纯度

>98% (HPLC)
溶解度

DMSO : 125 mg/mL 222.96 mM
SMILES

CCCC1=C(SC(=C1)C(=O)NC(CC2=CN=C(C=C2)C3=CC(=CC=C3)OC(F)(F)F)C(=O)NC4CCNC4)C
化学全称

5-methyl-N-((R)-1-oxo-1-(((R)-pyrrolidin-3-yl)amino)-3-(6-(3-(trifluoromethoxy)phenyl)pyridin-3-yl)propan-2-yl)-4-propylthiophene-2-carboxamide

1. Wu J, et al. ACS Chem Biol. 2013 Oct 18;8(10):2201-8.
2. Yang B, et al. J Med Chem. 2014 Dec 11;57(23):9958-70.

计算器

产品手册

关联产品

Dimethylenastron

A small molecule inhibitor of the mitotic kinesin Eg5; inhibits endothelial cell proliferation and migration in vitro.
Monastrol (b)

A potent, specific, allosteric and reversible mitotic kinesin Eg5 inhibitor with IC50 of 14 uM (microtubule motility inhibition).
GSK-923295

The first potent, allosteric inhibitor of CENP-E kinesin motor ATPase activity with Ki of 3.2 nM.