PF-2771 ( PF2771;PF 2771 )

产品货号. M17078 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

PF-2771
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

PF-2771 is a potent, selective CENP-E inhibitor with IC50 of 16.1 nM.
产品描述

PF-2771 is a potent, selective CENP-E inhibitor with IC50 of 16.1 nM; does not inhibit the ATPase activities of highly related kinesins (Eg5/KSP, chromokinesin and MCAK, IC50> 1 uM); selectively inhibits proliferation of basal breast cancer cell lines; regresses tumor growth correlated with increased phospho-HH3-Ser10 levels in a breast cancer xenograft tumor model.
同义词

PF2771;PF 2771
通路

Cytoskeleton/Cell Adhesion Molecules
靶点

Kinesin
受体

Kinesin
研究领域

——
适应症

——

CAS Number

——
分子量

554.08
分子式

C29H36ClN5O4
纯度

>98% (HPLC)
溶解度

DMSO: ≥ 32 mg/mL
SMILES

——
化学全称

(S)-N-(1-(4-(2-acetyl-1-methyl-1H-imidazol-4-yl)phenyl)-3-(2-(dimethylamino)acetamido)propan-2-yl)-3-chloro-4-isopropoxybenzamide

1. Kung PP, et al. Mol Cancer Ther. 2014 Aug;13(8):2104-15.

计算器

产品手册

关联产品

BRD 9876

BRD 9876 is an ATP- and ADP-competitive Eg5 (kinesin-5) inhibitor with Ki of 4 nM.
SR31527

SR31527 is a novel allosteric Kinesin-like protein KIFC1 inhibitor that inhibits microtubule-stimulated KIFC1 ATPase activity with IC50 of 6.6 uM.
Mps1-IN-2

Mps1-IN-2 is a potent Mps1 kianse inhibitor with IC50 value of 145 nM.