WZ8040 ( WZ8040; WZ8040; WZ 8040 )

产品货号. M17197 CAS No. 1214265-57-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

WZ8040
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I).
产品描述

WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor with potential anticancer activity. WZ8040 is about 30-fold more potent against EGFR T790M, and up to 100-fold less potent against wild-type EGFR, than other quinazoline-based EGFR inhibitors such as CL-387785 and HKI-272. WZ-8040 may be clinically more effective and better tolerated than quinazoline-based inhibitors.
同义词

WZ8040; WZ8040; WZ 8040
通路

Cytoskeleton/Cell Adhesion Molecules
靶点

Kinesin
受体

EGFR (T790M)
研究领域

Cancer
适应症

——

CAS Number

1214265-57-2
分子量

481.01
分子式

C24H25ClN6OS
纯度

98%
溶解度

——
SMILES

CN1CCN(CC1)C1=CC=C(NC2=NC=C(Cl)C(SC3=CC(NC(=O)C=C)=CC=C3)=N2)C=C1
化学全称

N-(3-((5-chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)thio)phenyl)acrylamide

1. Zhou W, et al. Nature, 2009, 462(7276), 1070-1074.

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产品手册

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