HR22C16 ( Monastroline )

产品货号. M14558 CAS No. 462630-41-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

HR22C16
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A potent, selective and cell permeable inhibitor of mitotic kinesin Eg5 with IC50 of 0.8 uM.
产品描述

A potent, selective and cell permeable inhibitor of mitotic kinesin Eg5 with IC50 of 0.8 uM, does not interact with other microtubule motor proteins; inhibits cell survival in both Taxol-sensitive and -resistant ovarian cancer cells with at least 15-fold greater efficacy than monastrol.
同义词

Monastroline
通路

Cytoskeleton/Cell Adhesion Molecules
靶点

Kinesin
受体

Kinesin
研究领域

——
适应症

——

CAS Number

462630-41-7
分子量

389.46
分子式

C23H23N3O3
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C(C1CC2=C(C(C3=CC=CC(O)=C3)N14)NC5=C2C=CC=C5)N(CCCC)C4=O
化学全称

2-butyl-5-(3-hydroxyphenyl)-5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione

1. Hotha S, et al. Angew Chem Int Ed Engl. 2003 May 30;42(21):2379-82.
2. Marcus AI, et al. J Biol Chem. 2005 Mar 25;280(12):11569-77.

计算器

产品手册

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