MK-8267 ( SCH 2047069 )

产品货号. M10516 CAS No. 1146209-50-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

MK-8267
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

MK-8267 (SCH 2047069) is a potent, orally bioavailable, brain penetrant kinesin spindle protein (KSP) inhibitor with EC50 of 3 nM.
产品描述

MK-8267 (SCH 2047069) is a potent, orally bioavailable, brain penetrant kinesin spindle protein (KSP) inhibitor with EC50 of 3 nM; inhibits a broader panel of 57 different tumor cell lines with IC50 <30 nM; showes significant brain uptake in mouse and rat with brain/plasma AUC ratio of 4 in rats, demonstrates anti-tumor activities in the tumor xenograft mouse model.
同义词

SCH 2047069
通路

Cytoskeleton/Cell Adhesion Molecules
靶点

Kinesin
受体

Kinesin
研究领域

——
适应症

——

CAS Number

1146209-50-8
分子量

439.43
分子式

C20H17F4N3O2S
纯度

>98% (HPLC)
溶解度

——
SMILES

——
化学全称

1-(3-(2-Aminoethyl)-5'-(2,5-difluorophenyl)-6,7-difluoro-3'H-spiro[chromane-4,2'-[1,3,4]thiadiazol]-3'-yl)ethan-1-one

1. Mansoor UF, et al. Bioorg Med Chem. 2015 May 15;23(10):2424-34.

计算器

产品手册

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