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首页- Products - Microbiology/Virology - HCV - Danoprevir

Danoprevir

CAS No. 850876-88-9

Danoprevir ( ITMN-191;R-7227;RO-5190591;RG-7227 )

产品货号. M16181 CAS No. 850876-88-9

A potent, highly selective, orally available, peptidomimetic HCV NS3/4A protease inhibitor with IC50 of 0.2-0.4 nM (GT1a, 1b, 4, 5 and 6), 1.6 nM (GT2b).

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ￥1126 有现货
10MG ￥2001 有现货
25MG ￥3418 有现货
50MG ￥5071 有现货
100MG ￥7201 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货
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生物学信息

  • 产品名称
    Danoprevir
  • 注意事项
    本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
  • 产品简述
    A potent, highly selective, orally available, peptidomimetic HCV NS3/4A protease inhibitor with IC50 of 0.2-0.4 nM (GT1a, 1b, 4, 5 and 6), 1.6 nM (GT2b).
  • 产品描述
    A potent, highly selective, orally available, peptidomimetic HCV NS3/4A protease inhibitor with IC50 of 0.2-0.4 nM (GT1a, 1b, 4, 5 and 6), 1.6 nM (GT2b); shows favorable potency profile against multiple HCV genotypes 1–6 and key mutants (replicon GT1b, EC50=1.6 nM).HCV Infection Approved
  • 同义词
    ITMN-191;R-7227;RO-5190591;RG-7227
  • 通路
    Microbiology/Virology
  • 靶点
    HCV
  • 受体
    HCVNS3/4Aprotease
  • 研究领域
    Infection
  • 适应症
    HCV Infection

化学信息

  • CAS Number
    850876-88-9
  • 分子量
    731.83
  • 分子式
    C35H46FN5O9S
  • 纯度
    >98% (HPLC)
  • 溶解度
    10 mM in DMSO
  • SMILES
    O=C(N1CC2=C(C(F)=CC=C2)C1)O[C@@H](C3)C[C@](C(N[C@@](C4)(C(NS(=O)(C5CC5)=O)=O)[C@]4([H])/C=C\CCCCCC6NC(OC(C)(C)C)=O)=O)([H])N3C6=O
  • 化学全称
    2H-Isoindole-2-carboxylic acid, 4-fluoro-1,3-dihydro-, (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a]

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Bae A, et al. Antimicrob Agents Chemother. 2010 Dec;54(12):5288-97.
2. Moucari R, et al. Gut. 2010 Dec;59(12):1694-8.
3. Jiang Y, et al. J Med Chem. 2014 Mar 13;57(5):1753-69.
4. Schaefer CJ, et al. Antimicrob Agents Chemother. 2011 Jul;55(7):3125-32.
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