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GSK-2336805
CAS No. 1256390-53-0
GSK-2336805 ( JNJ-56914845 | GSK2336805 | JNJ56914845 )
产品货号. M11048 CAS No. 1256390-53-0
GSK-2336805 (JNJ-56914845) 是一种新型有效的 HCV NS5A 抑制剂,具有多基因型活性。
纯度: >98% (HPLC)
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规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥11907 | 有现货 |
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50MG | ¥24138 | 有现货 |
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100MG | ¥32400 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称GSK-2336805
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述GSK-2336805 (JNJ-56914845) 是一种新型有效的 HCV NS5A 抑制剂,具有多基因型活性。
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产品描述GSK-2336805 (JNJ-56914845) is a novel potent HCV NS5A inhibitor with multigenotype activity, has EC50s of 58.5, 7.4, and 53.8 pM on genotype 1a (H77), genotype 1b (Con-1 ET), and genotype 2a (JFH-1) replicon cells; shows an average EC50 of 63.7 pM on genotype 2a Jc1 virus, inhibits the HCV replication cycle and production of virus; retains activity on chimeric replicons containing NS5A patient sequences from genotype 1 and patient and consensus sequences for genotypes 4 and 5 and part of genotype 6.HCV Infection Phase 2 Clinical.
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体外实验——
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体内实验——
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同义词JNJ-56914845 | GSK2336805 | JNJ56914845
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通路Microbiology/Virology
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靶点HCV
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受体HCV
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研究领域Infection
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适应症HCV Infection
化学信息
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CAS Number1256390-53-0
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分子量796.926
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分子式C42H52N8O8
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(OC)N[C@@H](C(C)C)C(N([C@H](C1=NC(C2=CC=C(C3=CC=C(C4=CNC([C@H]5N(C([C@H](C(C)C)NC(OC)=O)=O)CCC5)=N4)C=C3)C=C2)=CN1)C6)CC76OCCO7)=O
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化学全称methyl ((S)-1-((S)-8-(4-(4'-(2-((S)-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl)-1H-imidazol-4-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)-1,4-dioxa-7-azaspiro[4.4]nonan-7-yl)-3-methyl-1-oxobutan-2-yl)carbamate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Walker J, et al. Antimicrob Agents Chemother. 2014;58(1):38-47.
2. Kazmierski WM, et al. J Med Chem. 2014 Mar 13;57(5):2058-73.
3. Bourgeois S, et al. BMC Gastroenterol. 2017 Feb 10;17(1):26.
4. Wilfret DA, et al. Antimicrob Agents Chemother. 2013 Oct;57(10):5037-44.
产品手册
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