KIN101

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and RSV.

KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and RSV.(In Vitro):KIN101 results in a significant increase in the levels of ISGs as well as other proteins downstream of IRF activation such as RIG-I and MDA5.KIN101 (10 μM; 24 hours) causes a significant decrease in the NP protein abundance. KIN 101 (10 μM; 18 hours) shows a >1 log decrease in HCV RNA levels. KIN 101 (5, 10, 20, 50 μM; 4 hours) causes a dose-dependent decrease in influenza virus infection in MRC5 cells. KIN101 (0.01, 0.1, 1, 10, 100 μM) has a significant and dose-dependent effect on the formation of foci and has an IC50 of 0.2 μM.

3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene

Microbiology/Virology

HCV

NMDA

——

——

610753-87-2

395.2

C16H11BrO5S

>98% (HPLC)

——

CS(=O)(=O)Oc1ccc2c(c1)occ(-c1ccc(Br)cc1)c2=O

——

(-20℃)

With Ice Pack

≥ 2 years