LJH685

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

LJH685 是一种有效的 RSK1/2/3 泛 RSK 抑制剂 (IC50: 6/5/4 nM)。

LJH685 is an effective pan-RSK inhibitor for RSK1/2/3 (IC50: 6/5/4 nM).

LJH685 (0.01-100 μM; 72 hours) efficiently inhibits the growth of MDA-MB-231 and H358 cells in soft agar with EC50s of 0.73 and 0.79 μM, respectively.LJH685 (0.1-10 μM; 4 hours) efficiently reduces phosphorylation of YB1 at submicromolar concentrations and causes nearly complete inhibition at higher concentrations. Cell Proliferation Assay Cell Line:MDA-MB-231, H358 cells Concentration:0.01, 0.1, 1, 10, 100 μM Incubation Time:72 hours Result:The growth in soft agar was efficiently inhibited with EC50 values of 0.73 and 0.79 μM in MDA-MB-231 and H358, respectively.Western Blot Analysis Cell Line:MDA-MB-231, H358 cells Concentration:0.1, 0.3, 1, 3, 10 μM Incubation Time:4 hours Result:Efficiently reduced phosphorylation of YB1 at submicromolar concentrations and caused nearly complete inhibition at higher concentrations.

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LJH685 | NVP-LJH685 | NVP LJH685

Microbiology/Virology

HCV

RSK1| RSK2| RSK3

Cancer

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1627710-50-2

381.42

C22H21F2N3O

>98% (HPLC)

DMSO : ≥ 31 mg/mL 81.28 mM

CN1CCN(CC1)c1ccc(cc1)c1ccncc1c1cc(F)c(O)c(F)c1

2,6-Difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]-phenol

(-20℃)

With Ice Pack

≥ 2 years