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Telaprevir
CAS No. 402957-28-2
Telaprevir ( VX-950;VX950;VX 950 )
产品货号. M14381 CAS No. 402957-28-2
A potent, selective, covalent, orally bioavailable inhibitor of HCV NS3/4A protease with Ki of 7 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥786 | 有现货 |
|
| 10MG | ￥1312 | 有现货 |
|
| 25MG | ￥2098 | 有现货 |
|
| 50MG | ￥2900 | 有现货 |
|
| 100MG | ￥5322 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Telaprevir
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent, selective, covalent, orally bioavailable inhibitor of HCV NS3/4A protease with Ki of 7 nM.
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产品描述A potent, selective, covalent, orally bioavailable inhibitor of HCV NS3/4A protease with Ki of 7 nM; demonstrates excellent antiviral activity both in genotype 1b HCV replicon cells (IC50=354 nM) and in human fetal hepatocytes (IC50=280 nM); shows excellent viral inhibition in vivo with favorable pharmacokinetic profile.HCV Infection Approved
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同义词VX-950;VX950;VX 950
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通路Microbiology/Virology
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靶点HCV
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受体HCVNS3-4Aserineprotease
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研究领域Infection
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适应症HCV Infection
化学信息
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CAS Number402957-28-2
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分子量679.85
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分子式C36H53N7O6
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESO=C([C@@H]1[C@](CCC2)([H])[C@]2([H])CN1C([C@@H](NC([C@H](C3CCCCC3)NC(C4=NC=CN=C4)=O)=O)C(C)(C)C)=O)N[C@@H](CCC)C(C(NC5CC5)=O)=O
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化学全称Cyclopenta[c]pyrrole-1-carboxamide, (2S)-2-cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1S)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydro-, (1S,3aR,6aS)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Perni RB, et al. Antimicrob Agents Chemother. 2006 Mar;50(3):899-909.
2. Lin C, et al. J Biol Chem. 2004 Apr 23;279(17):17508-14.
3. Lin C, et al. J Biol Chem. 2005 Nov 4;280(44):36784-91.
2. Lin C, et al. J Biol Chem. 2004 Apr 23;279(17):17508-14.
3. Lin C, et al. J Biol Chem. 2005 Nov 4;280(44):36784-91.
产品手册
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