Ombitasvir ( ABT-267 )

产品货号. M20637 CAS No. 1258226-87-7

Ombitasvir 是一种口服生物利用度强的丙型肝炎病毒 (HCV) 非结构蛋白 5A (NS5A) 抑制剂。针对 HCV 基因型 1 至 5 的 EC50 为 0.82 至 19.3 pM，针对基因型 6a 的 EC50 为 366 pM。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥624	有现货
10MG	￥1021	有现货
25MG	￥1944	有现货
50MG	￥3507	有现货
100MG	￥5168	有现货
500MG	￥11097	有现货
1G	获取报价	有现货

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生物学信息

产品名称

Ombitasvir
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Ombitasvir 是一种口服生物利用度强的丙型肝炎病毒 (HCV) 非结构蛋白 5A (NS5A) 抑制剂。针对 HCV 基因型 1 至 5 的 EC50 为 0.82 至 19.3 pM，针对基因型 6a 的 EC50 为 366 pM。
产品描述

Ombitasvir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A).with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5 and 366 pM against genotype 6a.(In Vitro):Ombitasvir is active against the genotype 2a JFH-1 replicon, with an EC50 of 0.82 pM, and the EC50s of ombitasvir are 42 pM and 68 pM against the L28 and F28 variants of this genotype 6a replicon, respectively. In GT1a, variants M28V, L31V, and H58D confers 58- to 243-fold resistance to Ombitasvir. Single variants M28T, Q30R, and Y93C/S confers 800- to 8965-fold resistance, while Y93H/N confers >40000-fold resistance to Ombitasvir.
体外实验

Ombitasvir is active against the genotype 2a JFH-1 replicon, with an EC50 of 0.82 pM, and the EC50s of ombitasvir are 42 pM and 68 pM against the L28 and F28 variants of this genotype 6a replicon, respectively. In GT1a, variants M28V, L31V, and H58D confers 58- to 243-fold resistance to Ombitasvir. Single variants M28T, Q30R, and Y93C/S confers 800- to 8965-fold resistance, while Y93H/N confers >40000-fold resistance to Ombitasvir.
体内实验

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同义词

ABT-267
通路

Microbiology/Virology
靶点

HCV
受体

HCV NS5A
研究领域

Inflammation/Immunology
适应症

hepatitis C virus (HCV) infection

化学信息

CAS Number

1258226-87-7
分子量

894.11
分子式

C50H67N7O8
纯度

>98% (HPLC)
溶解度

DMSO:33 mg/mL (36.91 mM)
SMILES

COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)Nc1ccc(cc1)[C@@H]1CC[C@H](N1c1ccc(cc1)C(C)(C)C)c1ccc(NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)OC)C(C)C)cc1
化学全称

L-Prolinamide22'-(((2S5S)-1-(4-(11-dimethylethyl)phenyl)-25-pyrrolidinediyl)di-41-phenylene)bis(N-(methoxycarbonyl)-L-valyl-

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Krishnan P Beyer J Mistry Net al.in vitro and in vivo antiviral activity and resistance profile of ombitasvir an inhibitor of hepatitis c virus ns5a[J].Antimicrob Agents Chemother. 2015 Feb;59(2):979-87.

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