TAM Receptor
The impact of the TAM family of receptor protein tyrosine kinases (RTKs) on physiology recently gained momentum, as they play pivotal roles in several physiological systems. TYRO3, AXL and MERTK comprise the TAM family of RTKs, and together with their cognate ligands Growth Arrest-Specific 6 (GAS6) and Protein S (PROS1) mediate various molecular signaling pathways and cellular functions, mostly impacting adult tissues. All receptors share a similar domain structure. The extracellular domain is comprised of two immunoglobulin (Ig) type domains at the amino-most terminus. Two fibronectin type III domains are located adjacent to the transmembrane domain. Their kinase domain resides intracellularly, mediating various intracellular pathways, including PI3K/AKT, ERK/MAPK and JAK/STAT. The two chief functions mediated by TAM receptors in adult tissues are the phagocytic uptake of membranes and apoptotic cells, and negative regulation of the immune response. It should be mentioned that the overexpression and upregulation of TAMs is recognized in various human cancers, where activated TAM signaling functionally supports increased proliferation, migration, invasion, enhanced tumor cell survival, angiogenesis and promotes resistance to chemotherapeutic drugs.
References
1.Burstyn-Cohen T. Int J Dev Biol. 2017;61(3-4-5):215–224.
References
1.Burstyn-Cohen T. Int J Dev Biol. 2017;61(3-4-5):215–224.
Tyrosine Kinase
TAM Receptor
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Enapotamab
产品货号 : M36748
cas no: 1912423-61-0
Enapotamab 是一种 AXL/UFO 相关抗体,可用于合成 Bcl-xl 抑制剂抗体活性分子偶联物。 -
DS-1205
产品货号 : M28589
cas no: 1855860-24-0
DS-1205 是一种有效的选择性 AXL 激酶抑制剂,IC50 为 1.3 nM。 DS-1205 还抑制 MER、MET 和 TRKA,IC50 分别为 63、104 和 407 nM。 DS-1205可以抑制体外细胞迁移和体内肿瘤生长。 -
UNC569
产品货号 : M27388
cas no: 1350547-65-7
Lesinurad 是 URAT1 的选择性抑制剂,URAT1 是肾脏中的转运蛋白,可调节体内尿酸的排泄。 -
RU-302
产品货号 : M26815
cas no: 1182129-77-6
RU-302 是 TAM 受体的泛抑制剂,可阻断 TAM Ig1 胞外域和 Gas6 Lg 结构域之间的界面。 -
TAM-IN-2
产品货号 : M23970
cas no: 2135642-56-5
TAM-IN-2 是 TAM 的抑制剂。