FLT3
The FMS-like tyrosine kinase-3 (FLT-3) shares structural homology with other members of the class III receptor tyrosine kinase (RTK) family, such as KIT and FMS, with all members playing important roles in the survival, proliferation and differentiation of hematopoietic cells. FLT-3 is expressed in primitive CD34+ hematopoietic cells, dendritic cells, B-cell progenitors and natural killer cells. It has a limited range of tissue expression compared with FL, suggesting that FLT-3 is the major determinant of specificity. Wild-type FLT-3 appears to transduce its signaling cascade principally via the phosphotidylinositol-3 kinase (PI3K) and Ras pathways, leading to activation of AKT (protein kinase B), signal transducer and activator of transcription-5 (STAT5), and extracellular-signal regulated kinase-1 and -2 (ERK1/2). A number of compounds that target mutant and wild-type FLT-3 have recently been developed and are now in clinical trials.
References
1.Markovic A, et al. Int J Biochem Cell Biol. 2005;37(6):1168–1172.
References
1.Markovic A, et al. Int J Biochem Cell Biol. 2005;37(6):1168–1172.
Tyrosine Kinase
FLT3
-
Tetrahydrocoptisine
产品货号 : M17739
cas no: 7461-02-1
四氢黄连碱具有有效的抑制炎症作用。四氢黄连碱通过抑制 NF-κB 信号通路对 LPS 诱导的 ALI 具有保护作用,可能涉及抑制肺部炎症过程。 -
Maslinic acid
产品货号 : M17510
cas no: 4373-41-5
Maslinic Acid 是一种 DNA 聚合酶 B 抑制剂。 -
CGS 27023A
产品货号 : M17341
cas no: 161314-82-5
CGS 27023A 是一种非肽类、有效的、具有口服活性的溶质素抑制剂。 -
Trovirdine
产品货号 : M17324
cas no: 149488-17-5
Trovirdine 是一种硫脲类非核苷类逆转录酶抑制剂。 -
KIN1148
产品货号 : M17293
cas no: 1428729-56-9
KIN1148是一种新型小分子佐剂,通过RIG-I途径和IRF-3转录因子发挥作用,刺激inN/Ate免疫和病毒感染后的保护。