CSF1R
The colony-stimulating factor-1 receptor (CSF-1R) is known as macrophage colony-stimulating factor receptor (M-CSFR) or CD115. CSF1 receptor (CSF1R)-mediated signaling is crucial for the differentiation and survival of the mononuclear phagocyte system and macrophages in particular. CSF1R belongs to the type III protein tyrosine kinase receptor family, and binding of CSF1 or the more recently identified ligand, IL-34, induces homodimerization of the receptor and subsequent activation of receptor signaling. As the intratumoral presence of CSF1R+ macrophages correlates with poor survival in various tumor types, targeting CSF1R signaling in tumor-promoting TAM represents an attractive strategy to eliminate or repolarize these cells. CSF1R expression can be detected on other myeloid cells within the tumor microenvironment such as dendritic cells, neutrophils, and myeloid-derived suppressor cells (MDSCs). Expression of CSF-1 and/or CSF-1R has been documented in several human malignancies including breast, cervical, endometrial, ovarian, lung, prostate and kidney cancer, as well as in classical Hodgkin’s lymphoma (cHL) and anaplastic large cell lymphoma (ALCL).
References
1.Michael A. Cannarile,et al. J Immunother Cancer. 2017; 5: 53.
2.Achkova D,et al. Biochem Soc Trans. 2016 Apr 15;44(2):333-41.
References
1.Michael A. Cannarile,et al. J Immunother Cancer. 2017; 5: 53.
2.Achkova D,et al. Biochem Soc Trans. 2016 Apr 15;44(2):333-41.
Tyrosine Kinase
CSF1R
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Pimicotinib
产品货号 : M37228
cas no: 2253123-16-7
Pimicotinib 是一种具有抗肿瘤活性的 CSF1R 抑制剂。 -
Otilimab
产品货号 : M36826
cas no: 1638332-55-4
Otilimab (GSK 3196165) 是一种抗粒细胞-巨噬细胞集落刺激因子 (GM-CSF) 人源化单克隆抗体。Otilimab 通过阻断 GM-CSF 与其细胞表面受体的相互作用来中和 GM-CSF 的生物学功能。 -
Plonmarlimab
产品货号 : M36822
cas no: 2377482-36-3
Plonmarlimab (TJ003234) 是一种抗 GM-CSF 单克隆抗体。Plonmarlimab 可用于类风湿性关节炎和 COVID-19 的研究。 -
Gimsilumab
产品货号 : M36798
cas no: 1648796-29-5
Gimsilumab 是一种人源化的抗GM-CSF 单克隆抗体。Gimsilumab 具有研究 COVID-19 和 类风湿性关节炎的潜力。 -
Axatilimab
产品货号 : M36771
cas no: 2155851-88-8
Axatilimab (SNDX-6352) 是一种人源 IgG4 抗体,对 CSF-1R 具有高亲和力。Axatilimab 可用于慢性移植物抗宿主病 (cGVHD) 和肿瘤疾病的研究。