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UNC569
CAS No. 1350547-65-7
UNC569 ( —— )
产品货号. M27388 CAS No. 1350547-65-7
Lesinurad 是 URAT1 的选择性抑制剂，URAT1 是肾脏中的转运蛋白，可调节体内尿酸的排泄。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥437 | 有现货 |
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| 5MG | ￥721 | 有现货 |
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| 10MG | ￥1191 | 有现货 |
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| 25MG | ￥2657 | 有现货 |
|
| 50MG | ￥4358 | 有现货 |
|
| 100MG | ￥6221 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称UNC569
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Lesinurad 是 URAT1 的选择性抑制剂，URAT1 是肾脏中的转运蛋白，可调节体内尿酸的排泄。
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产品描述Lesinurad is a selective inhibitor of URAT1, a transporter in the kidney that regulates uric acid excretion from the body. It is also a selective uric acid re-absorption inhibitor. Lesinurad could normalize the amount of uric acid excreted by gout patients previously classified as under-excretors.
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体外实验Apoptosis Analysis Cell Line:697 and Jurkat cells Concentration:0.4 μM, 0.8 μM, 1 μM, 1.2 μM, 1.4 μM, 1.6 μM, 1.8 μM, 2 μM Incubation Time:24 hours Result:Induced apoptosis in ALL cell lines.Western Blot Analysis Cell Line:697 and Jurkat cells Concentration:1 μM Incubation Time:1.5 hours Result:Inhibited Mer activation and downstream signaling through ERK1/2 and AKT.
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体内实验——
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同义词——
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通路Tyrosine Kinase
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靶点TAM Receptor
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number1350547-65-7
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分子量396.514
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分子式C22H29FN6
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 31.25 mg/mL (78.81 mM)
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SMILESCCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(F)cc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Chathuranga K, Weerawardhana A, Dodantenna N, Ranathunga L, Cho WK, Ma JY, Lee JS. Inhibitory Effect of Sargassum fusiforme and Its Components on Replication of Respiratory Syncytial Virus In Vitro and In Vivo. Viruses. 2021 Mar 25;13(4):548. doi: 10.3390/v13040548. PMID: 33806073; PMCID: PMC8064456.
