ATPase
The electrochemical proton gradient across membranes and the acidic lumenal pH play vital bioenergetic or physiological roles in organelles, cells and tissues of animals and plants. They are required for ATP synthesis, solute transport, protein processing, exocytosis, endocytosis, etc. Proton-pumping ATPases are the major players in the transport of protons across membranes. The three classes of the ATPase family are the P-ATPase, F-ATPase and V-ATPase, the nomenclature being based on acyl phosphate intermediates, factors of oxidative phosphorylation and a pump found initially in vacuoles, respectively. F-ATPase and V-ATPase are similar in subunit structure and mechanism. However, F-ATPase is a ubiquitous ATP synthase in mitochondria, chloroplasts, and bacterial membranes, whereas V-ATPase is a proton pump in diverse endomembrane organelles such as lysosomes and endosomes.
References
1.Nakanishi-Matsui M,et al. IUBMB Life. 2006;58(5-6):318–322.
References
1.Nakanishi-Matsui M,et al. IUBMB Life. 2006;58(5-6):318–322.
Endocrinology/Hormones
ATPase
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ATPase-IN-3
产品货号 : M37359
cas no: 1134203-12-5
ATPase-IN-3 is an ATPase (ATPase) inhibitor that can be used in the study of metabolism-related diseases. -
PK095
产品货号 : M35967
cas no: 380314-37-4
PK095 是一种 p53 突变体稳定剂。PK095 可用于癌症研究。 -
Mtb ATP synthase-IN-1
产品货号 : M35484
cas no: 2642394-38-3
Mtb ATP synthase-IN-1 (compound 6ab) 是一种有效的 结核分枝杆菌 (Mtb) ATP 合成抑制剂,对 Mtb 的 MIC 为 0.452 ~ 0.499 μg/mL。Mtb ATP synthase-IN-1 代谢稳定性好,细胞毒性低 (Vero IC50 > 64 μg/mL),具有一定的口服生物利用度。Mtb ATP synthase-IN-1 可用于抗结核分枝杆菌的研究。 -
L-Palmitoylcarnitine chloride
产品货号 : M34932
cas no: 18877-64-0
L-Palmitoylcarnitine chloride是一种长链酰基肉碱和脂肪酸代谢产物,在缺血期间积聚于肌膜并扰乱膜脂环境。L-Palmitoylcarnitinechloride 通过与 Kir6.2 的相互作用抑制 KATP 通道活性,而不影响单通道电导。 -
Sodium oleate
产品货号 : M34835
cas no: 143-19-1
Sodium oleate (Oleic acid sodium) 是人脂肪细胞和其他组织中最常见的单不饱和脂肪酸钠盐。Sodium oleate 是一种 Na+/K+ ATP 酶激活剂。