5-HT Receptor
Serotonin (5-hydroxytryptamine, 5-HT) produces its effects through a variety of membrane-bound receptors. 5-HT and its receptors are found both in the central and peripheral nervous system (CNS/PNS), as well as in a number of nonneuronal tissues in the gut, cardiovascular system and blood. In evolutionary terms, 5-HT is one of the oldest neurotransmitters and has been implicated in the aetiology of numerous disease states, including depression, anxiety, social phobia, schizophrenia, and obsessive–compulsive and panic disorders; in addition to migraine, hypertension, pulmonary hypertension, eating disorders, vomiting and, more recently, irritable bowel syndrome (IBS).
5-HT is probably unique among the monoamines in that its effects are subserved by as many as 13 distinct heptahelical, G-protein-coupled receptors (GPCRs) and one (presumably a family of) ligand-gated ion channel(s). These receptors are divided into seven distinct classes (5-HT1 to 5-HT7) largely on the basis of their structural and operational characteristics.Not surprisingly, the 5-HT receptor family has been a long-standing target of intense research, in both the academia and the pharmaceutical industry, even before the complexity of the system was unravelled by molecular cloning.
References:
1.Hoyer D, et al. Pharmacol Biochem Behav. 2002 Apr;71(4):533-54.
5-HT is probably unique among the monoamines in that its effects are subserved by as many as 13 distinct heptahelical, G-protein-coupled receptors (GPCRs) and one (presumably a family of) ligand-gated ion channel(s). These receptors are divided into seven distinct classes (5-HT1 to 5-HT7) largely on the basis of their structural and operational characteristics.Not surprisingly, the 5-HT receptor family has been a long-standing target of intense research, in both the academia and the pharmaceutical industry, even before the complexity of the system was unravelled by molecular cloning.
References:
1.Hoyer D, et al. Pharmacol Biochem Behav. 2002 Apr;71(4):533-54.
Endocrinology/Hormones
5-HT Receptor
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CART (62-76) (rat, human)
产品货号 : M30706
cas no: 210978-19-1
Cocaine- and amphetamine-regulated transcript (CART) peptide fragment that inhibits food intake. Attenuates NPY-induced feeding and decreases food intake in food-restricted goldfish, and induces anxiogenic-like effects in elevated plus-maze test in rats. Modulates the activity of striatal noradrenergic, and corticostrial and hypothalamic serotoninergic systems, with no major effect on dopaminergic pathways in rat brain. -
Peptide 401
产品货号 : M30107
cas no: 32908-73-9
Peptide 401 is an antimicrobial peptide (AMP) derived from the venom of bees and wasps. Peptide 401 induces mast cell degranulation, activating histamine release from peritoneal mast cells. Additionally, peptide 401 exhibits some anti-inflammatory activity, decreasing paw edema in animal models. -
4-((5-cyclopropyl-3-methyl-1-((methylsulfonyl)methyl)-1H-pyrazol-4-yl)oxy)-2,6-dimethylbenzonitrile
产品货号 : M28498
cas no: 160777-43-5
4-((5-cycloryl-3-methyl-1-((methylsulfonyl)methyl)-1H-pyrazol-4-yl)oxy)-2,6-二甲基苯甲腈是 5-HT Receptor 的激动剂,具有抗阿尔茨海默病和抗抑郁活动。 -
pCPA methyl ester hydrochloride
产品货号 : M28343
cas no: 14173-40-1
pCPA甲酯盐酸盐是色氨酸羟化酶抑制剂和5-HT合成抑制剂。 pCPA 甲酯盐酸盐可透过血脑屏障并降低 5-HT 中枢利用率。 -
5-HT1A modulator 2 hydrochloride
产品货号 : M28119
cas no: 3880-76-0
5-HT1A调节剂2盐酸盐是一种5-HT1A调节剂,对5-HT1A结合的亲和力为53 nM。